DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14006 and Nemp1

DIOPT Version :9

Sequence 1:	NP_001260104.1	Gene:	CG14006 / 33802	FlyBaseID:	FBgn0031733	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001106682.1	Gene:	Nemp1 / 210035	MGIID:	2446113	Length:	437	Species:	Mus musculus

Alignment Length:	420	Identity:	82/420 - (19%)
Similarity:	139/420 - (33%)	Gaps:	161/420 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LLNMLYVNNQVQVYCQPPTAFSMWNVFQSNRLRLQIAAGEDYTQYKGATVREVHHAHSQLDECHE 112
            |:.:..|:|:.::  :....||:||.|.|                         ....:|::
Mouse    90 LVRVTQVDNEEKL--KELEQFSIWNFFSS-------------------------FLKEKLND--- 124

  Fly   113 GKPLGHSAADEPRIVPMATYEHSCYGIYTSKPFVLTLEVIS------------FDLERVSQFTFG 165
                              ||.:  .|:|::|. .|.:|:|.            ||.:....|..|
Mouse   125 ------------------TYVN--VGLYSTKT-CLKVEMIEKDTTYSVTVTRRFDPKLFLVFLLG 168

  Fly   166 IVLWLSCPLLADSLLFFYCSAAALGAHLAGLLAVAATLMASDGERYLRLGTLKVNFKLVLNERPT 230
            :.|:....||:.|.:|:|.:..::|. :|.||.|  ..|.|               |.:....|.
Mouse   169 LTLFFCGDLLSRSQIFYYSTGMSVGI-VASLLIV--IFMIS---------------KFMPKRSPI 215

  Fly   231 VITLALVSGAW-----LLKSASQRCSFLWR--------------------CTLFRRLHH----RL 266
            .:.|.   |.|     |::...:....:||                    |..:..|.:    .|
Mouse   216 YVILV---GGWSFSLYLIQLVFKNLQEIWRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSINL 277

  Fly   267 LKGTSYLL---ILTAS---DHRGFGMTCLMLL---MPWPELLTVIRWLKTLYACYKRGSVKPM-- 320
            |..|..||   ::.:|   .|..|.:..:.|.   :.:|     |.||.:.|....:.|.||:
Mouse   278 LTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYP-----IHWLCSTYRRMCKASGKPVPP 337

  Fly   321 ---------VQVEIENQ----------DVPYQDSYLRIVRSEYDNRSSESSGFSRSFSQNKHNMG 366
                     :|.|:|.|          :.|...::..|.|.:...|.::....|...:.|:.::
Mouse   338 RLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHLTPNEVSV- 401

  Fly   367 FYREQE-------DQDNALIYE---SRRPT 386
              .|||       .||..|..|   |..||
Mouse   402 --HEQEYGLGSIFTQDEELSSEEEGSEYPT 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14006	NP_001260104.1	DUF2215	146..345	CDD:287228	54/269 (20%)
Nemp1	NP_001106682.1	DUF2215	150..396	CDD:287228	53/271 (20%)
		A, required for its colocalization with lamins at the nuclear envelope. /evidence=ECO:0000269\|PubMed:25946333	184..295		25/131 (19%)
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:25946333	334..437		21/99 (21%)
		B, required for interaction with RAN-GTP. /evidence=ECO:0000269\|PubMed:25946333	334..403		11/71 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..437		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13598
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100