DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11149 and LARGE1

DIOPT Version :9

Sequence 1:NP_608952.2 Gene:CG11149 / 33800 FlyBaseID:FBgn0031732 Length:493 Species:Drosophila melanogaster
Sequence 2:NP_001349878.1 Gene:LARGE1 / 9215 HGNCID:6511 Length:756 Species:Homo sapiens


Alignment Length:561 Identity:108/561 - (19%)
Similarity:180/561 - (32%) Gaps:180/561 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LWPVLILFNVALLL-------------VWRNLQQAQKLAASSNTGGQKSVGLLLSNESNPSRFSA 65
            ||.|...|....:|             :|:|.:....|....|||    |.|||.::....::..
Human   254 LWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTG----VILLLLDKLRKMKWEQ 314

  Fly    66 NFHLANDQHPKIIRREDSARTKELRSLL--KCRDRSLRFERLQHGEFWLLQ-----NLVMGRKSR 123
            .:.|..:              :||..:|  ...|:.:....::...|.:.|     |:.:...:|
Human   315 MWRLTAE--------------RELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTR 365

  Fly   124 EVGCAESVTYTTNGDFTFFDNLEMVVSRWRAPVSFAIHTPGYDL--NTTLDAIRYVRN------- 179
            ...|...|:             ::.|..|.:|....:.....:.  |..|..:.|..|       
Human   366 SEQCYRDVS-------------DLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELF 417

  Fly   180 -CLPESD----SIKDWVS--------------------FHVYFPNQHMPEYVP-YDEAEVL---- 214
             |..|:|    :::..:|                    .|:||.:.   ||.| .|..:|.    
Human   418 GCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHY---EYEPAADSTDVTLVAQ 479

  Fly   215 -------MYPHMCTLANGSLVSPLYTQIPTTDSY----------KSRANL----------TYPIN 252
                   |...:|....|.:...||........:          .||.|:          .||:|
Human   480 LSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVN 544

  Fly   253 VGRNIARLATNTHFIFACDIELYPSVGFVDQFLDMVARNHSVLALDPRQRRRVYPLPVFE-IETG 316
            :.||:|....:|.::|..||:..|..|..:..      ..||:.||....::...:|.|| :...
Human   545 LLRNVAMKHISTPYMFLSDIDFLPMYGLYEYL------RKSVIQLDLANTKKAMIVPAFETLRYR 603

  Fly   317 AKVPVDKDELLALYRKQQAQVFHLKLCPTCHTIPGQEEWLNRTSRADDHLHVFSKALRKWKFRAW 381
            ...|..|.|||::.  ....:|..:                        .||::|......|..|
Human   604 LSFPKSKAELLSML--DMGTLFTFR------------------------YHVWTKGHAPTNFAKW 642

  Fly   382 EPFYVSDNTEPLFDERVTWEGQSNKRIQVSYYCSQVSVS----QCNLLLQNYAMCLLDYEYHVLS 442
            .     ..|.|.   ||.||......:.|...|.:....    ..|.:.....:.:.:||:.||.
Human   643 R-----TATTPY---RVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLP 699

  Fly   443 PAFLVHSPGIKQSSKADSTRLQYAKEMTKFIKNKIEPEYRV 483
            .|:::|.|      .|.|.      ::|||..||   :||:
Human   700 NAYMIHMP------HAPSF------DITKFRSNK---QYRI 725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11149NP_608952.2 Glyco_transf_49 130..485 CDD:290607 83/425 (20%)
LARGE1NP_001349878.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 43..69
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..109
GT8_LARGE_C 138..417 CDD:133053 33/193 (17%)
Xylosyltransferase activity. /evidence=ECO:0000305|PubMed:22223806 138..413 33/189 (17%)
Glucuronyltransferase activity. /evidence=ECO:0000305|PubMed:22223806 414..756 75/370 (20%)
Glyco_transf_49 473..742 CDD:404735 64/308 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146088
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3765
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D729091at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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