Protein Alignment CG11149 and large2

DIOPT Version :10

• Sequence 1: NP_608952.2
• Gene: CG11149 / 33800
• FlyBaseID: FBgn0031732
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_001004538.1
• Gene: large2 / 446214
• ZFINID: ZDB-GENE-050419-253
• Length: 750
• Species: Danio rerio
• Alignment Length: 550
• Identity: 107/550 - (19%)
• Similarity: 179/550 - (32%)
• Gaps: 195/550 - (35%)

  Fly    15 WPVLIL-FNVALLLVWRNLQQAQKLAASSN---TGGQKSVGLLLSNESNPSRFSANFHLANDQHP 75
            ||.|.. ||..::|::  |::.:::.....   |..::.:.:|.::.::...|:|..    .|:|
Zfish   282 WPALGRGFNTGVILLY--LERLRRMGWEQMWRLTAERELMSMLSTSLADQDIFNAFI----KQNP 340

  Fly    76 KIIRREDSARTKELRSLLKCRDRSLRFERLQHGEFWLLQNLVMGRKSREVGCAESVTYTTNGDFT 140
            .::.:            |.|              ||   |:.:...:|...|     ||...|
Zfish   341 VLVHQ------------LPC--------------FW---NVQLSDHTRSEQC-----YTEVSD-- 369

  Fly   141 FFDNLEMVVSRWRAPVSFAIHTPGYDL--NTTLDAIRYVRN--------C--------------- 180
                  :.|..|.:|....:.....:.  |..|..:.|..|        |
Zfish   370 ------LKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSQASSESTVLQQAL 428

  Fly   181 --LPESDSIKDW-------VSFHVYFPNQHMPEYVPYDEA------------EVLMYPHMCTLAN 224
              |.|.|...|:       ...|:||...   ||.|.|:.            .:.|...:|....
Zfish   429 EELDEDDQCYDFRRERIMLHRVHLYFLQY---EYSPTDDGTDITLVAQLSMDRLQMLEAICKHWE 490

  Fly   225 GSLVSPLYTQ----------IPTTDSYKSRANL----------TYPINVGRNIARLATNTHFIFA 269
            |.:...||..          ...::..|:|.|:          .||:|:.||:|....||.::|.
Zfish   491 GPISLALYMSDAEAQQFLRYAQASEVLKNRKNVGYHIVYKEGQFYPVNLVRNVALRNVNTPYVFL 555

  Fly   270 CDIELYPSVGFVDQFLDMVARNHSVLALDPRQRRRVYPLPVFE-IETGAKVPVDKDELLALYRKQ 333
            .|::..|..|..|..      ..|::.||....::...:|.|| :......|..|.|||::....
Zfish   556 TDVDFLPMYGLYDYL------RKSIVQLDMANTKKALVVPAFETLRYRLSFPKSKAELLSMLDMG 614

  Fly   334 QAQVFHLKL-----CPTCH------TIPGQEEWLNRTSRADDHLHVFSKALRKWKFRAWEPFYVS 387
            ....|...:     .||.:      |.|.:.||     .||                 :||:.|.
Zfish   615 TLYTFRYHVWTKGHAPTNYAKWRTATTPYKVEW-----EAD-----------------FEPYVVV 657

  Fly   388 DNTEPLFDERVTWEGQSNKRIQVSYYCSQVSVSQCNLLLQNYAMCLLDYEYHVLSPAFLVHSPGI 452
            ....|.:|:|....|. ||...:....:|                  :|:..||..||::|.|
Zfish   658 RRDCPEYDQRFVGFGW-NKVSHIMELDAQ------------------EYDLIVLPNAFMIHMP-- 701

  Fly   453 KQSSKADSTRLQYAKEMTKFIKNKIEPEYR 482
                .|.|.      :::||   :..|.||
Zfish   702 ----HAPSF------DISKF---RSSPSYR 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11149	NP_608952.2	Glyco_transf_49	130..486	CDD:464027	86/430 (20%)
large2	NP_001004538.1	GT8_LARGE_C	132..411	CDD:133053	30/176 (17%)
		Xylosyltransferase activity. /evidence=ECO:0000250|UniProtKB:O95461	132..407		30/172 (17%)
		Glucuronyltransferase activity. /evidence=ECO:0000250|UniProtKB:O95461	408..750		76/375 (20%)
		Glyco_transf_49	467..737	CDD:464027	64/313 (20%)