DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11149 and Large2

DIOPT Version :9

Sequence 1:	NP_608952.2	Gene:	CG11149 / 33800	FlyBaseID:	FBgn0031732	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	XP_006499317.1	Gene:	Large2 / 228366	MGIID:	2443769	Length:	715	Species:	Mus musculus

Alignment Length:	521	Identity:	106/521 - (20%)
Similarity:	188/521 - (36%)	Gaps:	133/521 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RLWPVLIL-FNVALLLVWRN-LQQAQKLAASSNTGGQKSVGLLLSNESNPSRFSANFHLANDQHP 75
            |.||.|.. ||..::|:|.: |||.........|..::.:.|:.::.::...|:|    ...:||
Mouse   241 RPWPALGRGFNTGVILLWLDRLQQTGWEQMWKVTAKRELLTLMATSLADQDIFNA----VIKEHP 301

  Fly    76 KIIRR-------EDSARTKELRSLLKCRD---------RSLRFERLQHGEFWLLQNLVM------ 118
            .::..       :.|..|:..|..|:..|         :.||.:. :|.||:  :||.:
Mouse   302 HLVHPLPCVWNVQLSDHTRAERCYLEAADLKVIHWNSPKKLRVKN-KHAEFF--RNLHLTFLGYD 363

  Fly   119 GRKSRE--VGC-----------AESVTYTTNGDFTF-FDNLEMVVSRWRAPVSFAIHTP----GY 165
            |:..|.  .||           .:::|.....:..| |...::.|.  |..::|..|.|    .:
Mouse   364 GKLLRRELFGCPNQFPPGAEQLQQALTQLDEEEPCFEFRQQQLTVH--RVHITFLPHQPPPPQPH 426

  Fly   166 DL----NTTLDAIRYVRN-CLPESDSIKDW---VSFHVYFPNQHMPEYVPYDEAEVLMYPHMCTL 222
            |:    ..::|.::.:.. |       :.|   :|..:|..::...:::.:.|...::     ::
Mouse   427 DVTLVAQLSMDRLQMLEALC-------RHWPGPMSLALYLTDEEAQQFLHFVETSPVL-----SM 479

  Fly   223 ANGSLVSPLYTQIPTTDSYKSRANLTYPINVGRNIARLATNTHFIFACDIELYPSVGFVDQFLDM 287
            ........:|...|           .||:|..||:|.....|.::|..||:..|:....|.....
Mouse   480 RKDVAYHVVYRDGP-----------LYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRAS 533

  Fly   288 VARNHSVLALDPRQRRRVYPLPVFE-IETGAKVPVDKDELLALYRKQQAQVFHLKLCPTCHTIPG 351
            :.:    |.||.| |:....:|.|| :......|..|.|||.|........|.....|..|:...
Mouse   534 IEQ----LELDSR-RKTALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHSSTD 593

  Fly   352 QEEWLNRTSRADDHLHVFSKALRKWKFRAWEPFYVSDNTEPLFDERVTWEGQSNKRIQVSYYCSQ 416
            ...|  |.::|...:        :|. ..:||:.|.....|.:|.|....|. ||...:....:|
Mouse   594 YSRW--REAQAPYSV--------QWS-ADYEPYVVVPRDCPRYDPRFVGFGW-NKVAHIIELDAQ 646

  Fly   417 VSVSQCNLLLQNYAMCLLDYEYHVLSPAFLVHSPGIKQSSKADSTRLQYAKEMTKFIKNKIEPEY 481
                              :||:.||..||.:|.|   .:...|.:|.            :..|.|
Mouse   647 ------------------EYEFLVLPEAFSIHLP---HAPSLDISRF------------RSSPTY 678

  Fly   482 R 482
            |
Mouse   679 R 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11149	NP_608952.2	Glyco_transf_49	130..485	CDD:290607	73/367 (20%)
Large2	XP_006499317.1	GT8_LARGE_C	93..372	CDD:133053	31/137 (23%)
Large2	XP_006499317.1	Glyco_transf_49	427..660	CDD:372794	58/290 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3765
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740