DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and CDKL2

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001317653.1	Gene:	CDKL2 / 8999	HGNCID:	1782	Length:	570	Species:	Homo sapiens

Alignment Length:	426	Identity:	179/426 - (42%)
Similarity:	251/426 - (58%)	Gaps:	56/426 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVS 111
            |::||.|..:||||||:|.|||:::||.:||:|:|:||:||..::|||:|||:|||.|:|.|||:
Human     1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVN 65

  Fly   112 LLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPE 176
            ||||.::|:|.:|||||.:.|:|.:||..|.|....:.::..:|.:.|:.:||....:|||||||
Human    66 LLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPE 130

  Fly   177 NILLTAQGQVKLCDFGFARML-SPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAEL 240
            |||::..|.||||||||||.| :|||.|||||||||||||||||||.:||..|||||||||..|:
Human   131 NILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEM 195

  Fly   241 VRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQN 305
            ..||.|:||.||:||||.|...||:|:|||.::|.:|..|.|:.||.....||||.:.|..|:
Human   196 FMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSE-- 258

  Fly   306 PLTIDFLKKCLDKDPTKRWSCEKLTKHSYF--DDYIAK---------QRELEHVNSLEAANLRQQ 359
             :.||..||||..||.||..|.:|..|.:|  |.:..:         |::..:|:..:.:..|::
Human   259 -VVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKK 322

  Fly   360 QLASQQFML----ATAAQQLQTGP----------------------AQAAAIAAARDKSKTSNTS 398
            :......::    ....|.....|                      ...|:.|:....|:||:..
Human   323 EKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNK 387

  Fly   399 LPLLPST----------QHHHHPHQDYVKLQPLNKN 424
              ::|||          .|..:|.   |.:.||..|
Human   388 --IVPSTSLKDCSNVSVDHTRNPS---VAIPPLTHN 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	157/287 (55%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	157/285 (55%)
CDKL2	NP_001317653.1	STKc_CDKL2_3	2..287	CDD:270836	157/287 (55%)
		S_TKc	4..287	CDD:214567	157/285 (55%)
		[NKR]KIAxRE	45..51		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S801
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770