DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and PRPF4B

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_003904.3	Gene:	PRPF4B / 8899	HGNCID:	17346	Length:	1007	Species:	Homo sapiens

Alignment Length:	342	Identity:	96/342 - (28%)
Similarity:	156/342 - (45%)	Gaps:	50/342 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YRPQGSSKMD-RYEKLSRLGEGSYGVVYKCRDR-ETGALVAVKRFVESEDDPAIRKIALREIRLL 101
            ||......:| ||......|:|.:..|.:.||. .....||||....:|   .::|..|:|:..|
Human   675 YRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNE---LMQKTGLKELEFL 736

  Fly   102 KNLKHP------NLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHL--TKQICYQTLL 158
            |.|...      :.:.|...|..|:.|.||||...:.:...|:::.:....|:  .:....|..|
Human   737 KKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFL 801

  Fly   159 GVAYCHKQGCLHRDIKPENILLTAQGQV-KLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDT 222
            .:....:...||.||||:|||:.....: ||||||.|..::..: .|.|:.:|:|||||:::|.:
Human   802 ALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-ITPYLVSRFYRAPEIIIGKS 865

  Fly   223 -QYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHI-------QIFGQNEY 279
             .||  :|:|::||...||..|:.|:||:::...|.|.....|.:..:.|       |.|.||..
Human   866 YDYG--IDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLN 928

  Fly   280 FKGI---------TLPVPPTLEPLED---------KMPAKSQQNPLTIDFLKKCLDK----DPTK 322
            |..|         .:.|..|:.|.:|         ::|...::.   :..||..||:    ||.|
Human   929 FMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKK---VHQLKDLLDQILMLDPAK 990

  Fly   323 RWSCEKLTKHSYFDDYI 339
            |.|..:..:|::..:.|
Human   991 RISINQALQHAFIQEKI 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	93/327 (28%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	91/324 (28%)
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..533
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..583
		STKc_PRP4	686..1003	CDD:271037	92/325 (28%)
		S_TKc	694..1003	CDD:214567	90/317 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910