DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and CDKL1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_005268214.1	Gene:	CDKL1 / 8814	HGNCID:	1781	Length:	358	Species:	Homo sapiens

Alignment Length:	363	Identity:	207/363 - (57%)
Similarity:	264/363 - (72%)	Gaps:	20/363 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVS 111
            |::|||:.::||||||||:|||:|:||.:||:|:|:||||||.|:||||||||:||.|||||||:
Human     2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVN 66

  Fly   112 LLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPE 176
            ||||||||||||||||:|:.||||||:|:.:|.||||.|.|.:|||..|.:|||..|:|||:|||
Human    67 LLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPE 131

  Fly   177 NILLTAQGQVKLCDFGFARMLS-PGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAEL 240
            |||:|....:|||||||||:|: |.:.|||||||||||:|||||||||||.|||||||||:||||
Human   132 NILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAEL 196

  Fly   241 VRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQN 305
            :.|..||||:||||||||||||||||:|||.|:|..|:||.|:.:|.|..:||||.|.|..|..
Human   197 LSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYP- 260

  Fly   306 PLTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNSLEAANLRQQQLASQQFMLAT 370
              .:..||.||..|||:|.:||:|..|.||::.    ||:|.:........|:....|::....|
Human   261 --ALGLLKGCLHMDPTQRLTCEQLLHHPYFENI----REIEDLAKEHNKPTRKTLRKSRKHHCFT 319

  Fly   371 AAQQLQTGPAQAAAIAAARDKSKTSNTSLPLLPSTQHH 408
            ...:||..|            ..|.::.||.|.:.:::
Human   320 ETSKLQYLP------------QLTGSSILPALDNKKYY 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	191/287 (67%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	191/285 (67%)
CDKL1	XP_005268214.1	STKc_CDKL1_4	3..288	CDD:270837	191/287 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55805
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1779
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52261
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	1	1.000	-	-		FOG0004639
OrthoInspector	1	1.000	-	-		otm41930
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3077
SonicParanoid	1	1.000	-	-		X3254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	13.010