DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7236 and Cilk1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_620241.1	Gene:	Cilk1 / 84411	RGDID:	71050	Length:	629	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	130/404 - (32%)
Similarity:	199/404 - (49%)	Gaps:	61/404 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVK----RFVESEDDPAIRKIALREIRLLKNLKHP 107
            |:||..:.:||:|:||.|...|..|:|.|:|:|    :|...|:     .:.|||::.||.|.|.
  Rat     1 MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE-----CMNLREVKSLKKLNHA 60

  Fly   108 NLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRD 172
            |:|.|.||.|....|:.:||:.:..:...::...:..||...:.|.||.|.|:|:.||.|..|||
  Rat    61 NIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRD 125

  Fly   173 IKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLF 237
            :||||:|......||:.|||.||.:.....|||||:||||||||:|:..|.|.:|:||||:||:.
  Rat   126 LKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIM 190

  Fly   238 AELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLP----------VPPTLE 292
            ||:.....|:||.|::|.::.|.:.||  .|:      :.::.:|..|.          :|..|:
  Rat   191 AEVYTLRPLFPGASEIDTIFKICQVLG--TPK------KTDWPEGYQLSSAMNFIWPQCIPNNLK 247

  Fly   293 PLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNSLEAANLR 357
            .|   :|..|.:   .|..|:..|..||.||.:..:..::.||        ::.|...:...:..
  Rat   248 TL---IPNASSE---AIQLLRDLLQWDPKKRPTASQALRYPYF--------QIGHPLGISTQDSG 298

  Fly   358 QQQLASQQFMLATAAQQLQTGP---AQAAAIAAARDKSKTSNTSLPLLPSTQHHHHPHQDYVKLQ 419
            :.|...|.          :|||   .:.|..|.|..|:.|..:|.|...|     .|||.:|  .
  Rat   299 KPQKDVQD----------KTGPPPYVKPAPPAQAPTKAHTLISSRPNQAS-----QPHQHFV--Y 346

  Fly   420 PLNKNANLLHRTEH 433
            |....|:...:..|
  Rat   347 PYKGEASRTEQLSH 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	106/300 (35%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	105/298 (35%)
Cilk1	NP_620241.1	STKc_MAK_like	4..284	CDD:270824	105/298 (35%)
		S_TKc	4..284	CDD:214567	105/298 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..322		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..482
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..629
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910