DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and Cdkl1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_899117.1	Gene:	Cdkl1 / 71091	MGIID:	1918341	Length:	352	Species:	Mus musculus

Alignment Length:	378	Identity:	214/378 - (56%)
Similarity:	268/378 - (70%)	Gaps:	39/378 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVS 111
            |::|||:.::||||||||:|||:|:||.:||:|||:|:||||.|:||||||||:||.|||||||:
Mouse     1 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVN 65

  Fly   112 LLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPE 176
            ||||||||||||||||:|:.||||||:|:.:|.||.|.|.|.:|||..|.:|||..|:|||:|||
Mouse    66 LLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPE 130

  Fly   177 NILLTAQGQVKLCDFGFARMLS-PGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAEL 240
            |||:|.|..:|||||||||:|: ||:.|||||||||||:|||||||||||.|||||||||:||||
Mouse   131 NILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAEL 195

  Fly   241 VRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQN 305
            :.|..||||:||||||||||||||||:|||.|:|..|:||.|:.:|.|..:|.||.|.|..|..
Mouse   196 LSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPNISYS- 259

  Fly   306 PLTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNSLEA-ANLRQ--QQLASQQFM 367
              .:.|||.||..||.:|.:||:|.:|.|||. |.:..||...:...| ..|||  :.|...|::
Mouse   260 --ALGFLKGCLHMDPAERLTCEQLLQHPYFDS-IREVGELTRQHDKPARKTLRQSRKHLTGLQYL 321

  Fly   368 LATAAQQLQTGPAQAAAIAAARDKSKTSNTSLPLLPSTQHH--------HHPH 412
                 .||                  ||:..||.|.:.::|        |.|:
Mouse   322 -----PQL------------------TSSRILPALDNKKYHCSTKRFNYHFPN 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	191/287 (67%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	191/285 (67%)
Cdkl1	NP_899117.1	STKc_CDKL1_4	2..287	CDD:270837	191/287 (67%)
Cdkl1	NP_899117.1	[NKR]KIAxRE	45..51		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55805
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1778
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52261
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	1	1.000	-	-		FOG0004639
OrthoInspector	1	1.000	-	-		otm43978
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3077
SonicParanoid	1	1.000	-	-		X3254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.010