DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and CDKL5

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001032420.1	Gene:	CDKL5 / 6792	HGNCID:	11411	Length:	1030	Species:	Homo sapiens

Alignment Length:	412	Identity:	154/412 - (37%)
Similarity:	224/412 - (54%)	Gaps:	56/412 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLK 105
            |...:.|:::|.|..:|||:||||.|||.:||..:||:|:|.:||::..:::..|||:::|:.||
Human     4 PNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLK 68

  Fly   106 HPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLH 170
            ..|:|.|.|.|||:.:|:||||:.|..:|..||..|.|.|....|...||.:..:.:|||...:|
Human    69 QENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVH 133

  Fly   171 RDIKPENILLTAQGQVKLCDFGFARMLSPGE--NYTDYVATRWYRAPELLVGDTQYGTPVDVWAI 233
            |||||||:|::....:|||||||||.||.|.  |||:||||||||:||||:| ..||..||:|::
Human   134 RDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APYGKSVDMWSV 197

  Fly   234 GCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKM 298
            ||:..||..|:.|:||.|::|||:.|:|.||.|....:::|..|..|.|:..|.....:.||.:.
Human   198 GCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRY 262

  Fly   299 PAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELE------------HVNSL 351
              ....|.:.:|.:|..|..||..|:..|:...|..|.    .||.|:            ||.|.
Human   263 --LGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ----TQRLLDRSPSRSAKRKPYHVESS 321

  Fly   352 EAANLRQ------------------QQL------------ASQQFM---LATAA-QQLQTGPAQA 382
            ..:|..|                  |.|            |::.|:   ||.|: ..|.|...||
Human   322 TLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQA 386

  Fly   383 AAIAAARDKSKTSNTSLPLLPS 404
            ::...:..|..|:| ::|.|.|
Human   387 SSQPGSTSKDLTNN-NIPHLLS 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	126/288 (44%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	126/286 (44%)
CDKL5	NP_001032420.1	STKc_CDKL5	11..297	CDD:270838	126/288 (44%)
		S_TKc	13..297	CDD:214567	126/286 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..349		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..566		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820