DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and STK4

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_005260587.1	Gene:	STK4 / 6789	HGNCID:	11408	Length:	503	Species:	Homo sapiens

Alignment Length:	374	Identity:	105/374 - (28%)
Similarity:	168/374 - (44%)	Gaps:	76/374 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QSLQNSFLYRLIQKIQVCNEPDLVETRQYRPQGSSKMDR-----YEKLSRLGEGSYGVVYKCRDR 70
            |.|.|. |:.|:..    :|||:  .||.:......:.:     ::.|.:|||||||.|||...:
Human     9 QCLPNG-LHILLSS----SEPDI--GRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHK 66

  Fly    71 ETGALVAVKRF-VESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVL 134
            |||.:||:|:. |||:    :::| ::||.:::....|::|.....:.:...|.:|.|:|....:
Human    67 ETGQIVAIKQVPVESD----LQEI-IKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSV 126

  Fly   135 HELER-HPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLS 198
            .::.| ..:...|.....|...||.|:.|.|....:|||||..||||..:|..||.|||.|..|
Human   127 SDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQL- 190

  Fly   199 PGENYTDYVATR-------WYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQL 256
                 ||.:|.|       ::.||| ::.:..|....|:|::|....|:..|:
Human   191 -----TDTMAKRNTVIGTPFWMAPE-VIQEIGYNCVADIWSLGITAIEMAEGK------------ 237

  Fly   257 YLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPT 321
                       |.:..|......|...|.| |||.     :.|.....|  ..||:|:||.|.|.
Human   238 -----------PPYADIHPMRAIFMIPTNP-PPTF-----RKPELWSDN--FTDFVKQCLVKSPE 283

  Fly   322 KRWSCEKLTKHSYFDDYIAKQRELEHVNSL-----EAANLRQQQLASQQ 365
            :|.:..:|.:|.:.       |..:.|:.|     ||.:::.::..|||
Human   284 QRATATQLLQHPFV-------RSAKGVSILRDLINEAMDVKLKRQESQQ 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	87/300 (29%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	87/293 (30%)
STK4	XP_005260587.1	STKc_MST1_2	42..297	CDD:132943	87/297 (29%)
		S_TKc	46..297	CDD:214567	87/293 (30%)
		Mst1_SARAH	449..496	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910