DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and TAOK1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_065842.1	Gene:	TAOK1 / 57551	HGNCID:	29259	Length:	1001	Species:	Homo sapiens

Alignment Length:	393	Identity:	114/393 - (29%)
Similarity:	175/393 - (44%)	Gaps:	71/393 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPDLVETRQYRPQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIR-KI 93
            :|::.|.  :..:...|:  :..|..:|.||:|.||..||..|..:||:|:...|......: :.
Human    12 DPEIAEL--FFKEDPEKL--FTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQD 72

  Fly    94 ALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLL 158
            .::|::.|:.:||||.:.....:.|:....||.|:|..:....||.|.:...|.....|.:..|.
Human    73 IIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQ 137

  Fly   159 GVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVG--D 221
            |:||.|....:|||||..|||||..|||||.|||.|.|.||..:   :|.|.::.|||:::.  :
Human   138 GLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANS---FVGTPYWMAPEVILAMDE 199

  Fly   222 TQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLP 286
            .||...||||::|....||...:......:.:..||            ||   .|||
Human   200 GQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALY------------HI---AQNE-------- 241

  Fly   287 VPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKHSY---------FDDYIAKQ 342
             .|||:        .::.:....:|:..||.|.|..|.:.|:|.||.:         ..|.|  |
Human   242 -SPTLQ--------SNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLI--Q 295

  Fly   343 RELEHVNSLEAANLRQQQLASQQFMLATAAQQLQTGPA-QAAAIAAARD---------KSKTSNT 397
            |..:.|..|:  ||:.:::....|      |:...||| :|......:|         .|..||.
Human   296 RTKDAVRELD--NLQYRKMKKLLF------QEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQ 352

  Fly   398 SLP 400
            |:|
Human   353 SIP 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	91/298 (31%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	91/296 (31%)
TAOK1	NP_065842.1	STKc_TAO1	2..318	CDD:270805	103/354 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..433		9/32 (28%)
		SbcC	<442..>877	CDD:223496
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910