DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and Cdkl2

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_058608.1	Gene:	Cdkl2 / 53886	MGIID:	1858227	Length:	568	Species:	Mus musculus

Alignment Length:	315	Identity:	158/315 - (50%)
Similarity:	219/315 - (69%)	Gaps:	9/315 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVS 111
            |::||.|..:||||||:|.|||::::|.:||:|:|:||:||..::|||:|||:|||.|:|.|||:
Mouse     1 MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVN 65

  Fly   112 LLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPE 176
            ||||.::|:|.:|||||.:.|:|.:|:..|.|....:.::..:|.:.|:.:||....:|||||||
Mouse    66 LLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPE 130

  Fly   177 NILLTAQGQVKLCDFGFARML-SPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAEL 240
            |||::..|.||||||||||.| :|||.|||||||||||||||||||.:||..||:||||||..|:
Mouse   131 NILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEM 195

  Fly   241 VRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLP--VPPTLEPLEDKMPAKSQ 303
            :.|:.|:||.||:|||:.|...||:|:|||.::|.:|..|.|:.||  .....||||.:.|...:
Mouse   196 LMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLPE 260

  Fly   304 QNPLTIDFLKKCLDKDPTKRWSCEKLTKHSYFD-DYIAKQ--RELEHVNSLEAAN 355
               ..|...||||..||.||..|..|.:|.:|. |..|::  :||:.....:|.|
Mouse   261 ---AVISLAKKCLHIDPDKRPFCADLLRHDFFQMDGFAERFSQELQLKIEKDARN 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	150/289 (52%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	150/287 (52%)
Cdkl2	NP_058608.1	STKc_CDKL2_3	2..289	CDD:270836	150/289 (52%)
		[NKR]KIAxRE	45..51		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..333		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820