DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and TAOK3

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001333416.1	Gene:	TAOK3 / 51347	HGNCID:	18133	Length:	907	Species:	Homo sapiens

Alignment Length:	451	Identity:	111/451 - (24%)
Similarity:	182/451 - (40%)	Gaps:	135/451 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LSRLGEGSYGVVYKCRDRETGALVAVKRFVES--------EDDPAIRKIALREIRLLKNLKHPNL 109
            |..:|.||:|.||...:..|..:||:|:...|        :|       .|:|::.|:.|||||.
Human    27 LHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQD-------ILKEVKFLRQLKHPNT 84

  Fly   110 VSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIK 174
            :.....:.::....||.|:|..:....||.|.:...|.....|.:..|.|:||.|....:|||||
Human    85 IEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIK 149

  Fly   175 PENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVG--DTQYGTPVDVWAIGCLF 237
            ..|||||..|||||.|||.|.|.||..:   :|.|.::.|||:::.  :.||...||:|::|...
Human   150 AGNILLTEPGQVKLADFGSASMASPANS---FVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITC 211

  Fly   238 AELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKS 302
            .||...:......:.:..||            ||   .||:         .|||
Human   212 IELAERKPPLFNMNAMSALY------------HI---AQND---------SPTL----------- 241

  Fly   303 QQNPLTID---FLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNSL---------EAAN 355
            |.|..|..   |:..||.|.|.:|.:..:|.:|    |::.:.|.|..:..|         |..|
Human   242 QSNEWTDSFRRFVDYCLQKIPQERPTSAELLRH----DFVRRDRPLRVLIDLIQRTKDAVRELDN 302

  Fly   356 LRQQQLASQQFMLATAAQQLQTGP--------------------------------------AQA 382
            |:.:::....|      |:.:.||                                      :|:
Human   303 LQYRKMKKILF------QETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQS 361

  Fly   383 AAIAAARDKSKTSNTSLPLLPSTQHHHHPHQDYVKLQPLNKNANLLHR--------TEHHL 435
            :::.:.::....|::.|.::         |.|.   ..:|.:::::|:        ||.|:
Human   362 SSVNSMQEVMDESSSELVMM---------HDDE---STINSSSSVVHKKVGFLVPSTEDHV 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	90/294 (31%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	90/294 (31%)
TAOK3	NP_001333416.1	STKc_TAO3	2..314	CDD:270803	98/341 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..362		3/45 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910