DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and WEE2

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001099028.1	Gene:	WEE2 / 494551	HGNCID:	19684	Length:	567	Species:	Homo sapiens

Alignment Length:	478	Identity:	105/478 - (21%)
Similarity:	160/478 - (33%)	Gaps:	153/478 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YLPQSLQNSFLY----RLIQKIQVCNEPDLVETRQYRPQG-----------SSKMDRYEK----L 53
            :.|:|.:..||.    |.|:       .||.|......:|           ::...||||    :
Human   158 FTPESYKKLFLQSGGKRKIR-------GDLEEAGPEEGKGGLPAKRCVLRETNMASRYEKEFLEV 215

  Fly    54 SRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNL-KHPNLVSLLEVFR 117
            .::|.|.:|.||||..|..|.:.|:||.:::..:.:....||.|:.....| .||::|.....:.
Human   216 EKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWA 280

  Fly   118 RKRRLHLVFEFCE----LTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENI 178
            ....:.:..|:|.    ...:.|..:......|...|.|..|..||:.|.|....:|.||||.||
Human   281 EDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNI 345

  Fly   179 -----------------------LLTAQGQVKLCDFGFARMLS-----PGENYTDYVATRWYRAP 215
                                   .|:|....|:.|.|.|..::     .|::.        :.|.
Human   346 FICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSR--------FLAN 402

  Fly   216 ELLVGDTQYGTPVDVWAIGCLFAELVRGEAL------WPGRSDVDQLYLIRKTLGDLLPRHIQIF 274
            |:|..|.::....|::|:|...|.....|:|      |                     .||:
Human   403 EILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAW---------------------HHIR-- 444

  Fly   275 GQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYI 339
                  ||....||..|......:             ||..:..|..:|.|...|.:::.....:
Human   445 ------KGNFPDVPQELSESFSSL-------------LKNMIQPDAEQRPSAAALARNTVLRPSL 490

  Fly   340 AKQRELEHVNSLEAANLRQQQLASQQFMLAT------AAQQLQ-----------------TGPAQ 381
            .|..||            ||||..::|..||      .|||.|                 ||...
Human   491 GKTEEL------------QQQLNLEKFKTATLERELREAQQAQSPQGYTHHGDTGVSGTHTGSRS 543

  Fly   382 AAAIA---AARDKSKTSNTSLPL 401
            ...:.   :||..|.||....||
Human   544 TKRLVGGKSARSSSFTSGEREPL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	72/329 (22%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	71/327 (22%)
WEE2	NP_001099028.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117
		Nuclear localization signal. /evidence=ECO:0000250	173..175		0/1 (0%)
		PTKc_Wee1b	211..485	CDD:271041	68/323 (21%)
		Pkinase	212..480	CDD:278497	67/317 (21%)
		Nuclear export signal. /evidence=ECO:0000250	315..329		5/13 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..567		13/53 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910