DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7236 and cdkl1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001003773.1	Gene:	cdkl1 / 445316	ZFINID:	ZDB-GENE-040808-34	Length:	350	Species:	Danio rerio

Alignment Length:	393	Identity:	207/393 - (52%)
Similarity:	271/393 - (68%)	Gaps:	44/393 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVS 111
            |::|||:|::||||||||:|||:::||.:||:|:||||||||.|:||||||||:||.|||||||:
Zfish     1 MEKYEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIRMLKQLKHPNLVN 65

  Fly   112 LLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPE 176
            |:|||||||:||||||:|:.|||:||:|:|:|.|||:.|.|.:|||..|.:||||.|:|||:|||
Zfish    66 LMEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPE 130

  Fly   177 NILLTAQGQVKLCDFGFARMLS-PGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAEL 240
            |||:|....:|||||||||:|: |.:.|||.|||||||||||||||||||.||||||:||:||||
Zfish   131 NILITKHQVIKLCDFGFARILTGPCDYYTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAEL 195

  Fly   241 VRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQN 305
            :.|..||||:||||||||||||||:|:|||.|:|..|::|.|:.:|.|..:||||.|.|..|.|
Zfish   196 LSGAPLWPGKSDVDQLYLIRKTLGELIPRHQQVFSTNQFFSGVCVPEPQEMEPLELKYPNLSYQ- 259

  Fly   306 PLTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNSLEAANLRQQQLASQQFMLAT 370
              .:..:|.||..||.:|.|||:|.:..|||   :.:.|.|.|.         ::|..::   .|
Zfish   260 --ALSLMKGCLRMDPAERLSCEQLLEQPYFD---SLREESESVT---------RELDRKK---RT 307

  Fly   371 AAQQLQTGPAQAAAIAAARDKSKTSNTSLPLLPSTQHHHHPHQDYVKLQPLNKNANLLHRTEHHL 435
            ...:....|.....:|        |:|..|.:.:                 .:|.|.|.:..:||
Zfish   308 RQPRKHLPPGYLPQLA--------SSTVFPAVEN-----------------RRNYNNLRKFNYHL 347

  Fly   436 PTI 438
            |.|
Zfish   348 PNI 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	186/287 (65%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	186/285 (65%)
cdkl1	NP_001003773.1	STKc_CDKL1_4	2..287	CDD:270837	186/287 (65%)
		Pkinase	4..287	CDD:278497	186/285 (65%)
		[NKR]KIAxRE	45..51		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..318		6/36 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	405	1.000	Domainoid score	I679
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55805
Inparanoid	1	1.050	412	1.000	Inparanoid score	I1825
OMA	1	1.010	-	-		QHG52261
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	1	1.000	-	-		FOG0004639
OrthoInspector	1	1.000	-	-		oto40394
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3254
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.980