DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and CDKL4

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001333840.1	Gene:	CDKL4 / 344387	HGNCID:	19287	Length:	379	Species:	Homo sapiens

Alignment Length:	366	Identity:	197/366 - (53%)
Similarity:	269/366 - (73%)	Gaps:	22/366 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVS 111
            |::||||::.||||||||:|||::.:|.:||||:||||||||.::||||||||:||.|||||||:
Human     1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVN 65

  Fly   112 LLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPE 176
            |:|||||||::|||||:|:.|:|:||||:|.|..:.:.|.:.:|||..:.:||...|:|||||||
Human    66 LIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPE 130

  Fly   177 NILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELV 241
            |||:|.||.:|:||||||::|.||:.|||||||||||||||||||||||:.||:|||||:||||:
Human   131 NILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELL 195

  Fly   242 RGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNP 306
            .|:.||||:|||||||||.:|||.|:|||..||..|.:|.||::|.|..:|.||:|.   |..:|
Human   196 TGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKF---SDVHP 257

  Fly   307 LTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNSLEAANLRQQQLASQ----QFM 367
            :.::|:|.||..:|..|.:|.:|.:.||||.:  ::.:::.....|..|.|:||.|.:    :..
Human   258 VALNFMKGCLKMNPDDRLTCSQLLESSYFDSF--QEAQIKRKARNEGRNRRRQQQAPKSAFPRLF 320

  Fly   368 LATAAQQLQTGPAQAAAIAAARDKSKTS-NTSLPLLPSTQH 407
            |.|...|:|            |::::|| |..||..|..|:
Human   321 LKTKICQVQ------------RNETQTSGNQILPNGPILQN 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	175/286 (61%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	175/284 (62%)
CDKL4	NP_001333840.1	[NKR]KIAxRE	45..51		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1779
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52261
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	1	1.000	-	-		FOG0004639
OrthoInspector	1	1.000	-	-		otm41930
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.080