DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and mark3a

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_021336197.1	Gene:	mark3a / 334300	ZFINID:	ZDB-GENE-030131-6232	Length:	746	Species:	Danio rerio

Alignment Length:	471	Identity:	114/471 - (24%)
Similarity:	192/471 - (40%)	Gaps:	95/471 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VETRQYRPQGSSK------------MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESED 86
            |.:|..|..|.::            :..|..|..:|:|::..|...|...||:.||:|...:::.
Zfish    29 VTSRSVRSSGRNRNSGSGLDDVHPVIGNYRLLKTIGKGNFAKVKLARHILTGSEVAIKMIDKTQL 93

  Fly    87 DP-AIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCE-LTVLHELERHPQGCPEHLT 149
            :| :::|:: ||:.::|||.|||:|.|.||...::.|.||.|:.. ..|...|..|.: ..|...
Zfish    94 NPTSLQKLS-REVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFDYLVAHGR-MKEKEA 156

  Fly   150 KQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRA 214
            :....|.:..|.|||::..:|||:|.||:||.....:|:.||||:.....|.....:..:..|.|
Zfish   157 RAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAA 221

  Fly   215 PELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGR---------------------SDVDQL-- 256
            |||..|....|..||||::|.:...||.|...:.|:                     :|.:.|
Zfish   222 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLK 286

  Fly   257 -YLI-----RKTLGDLL-PRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKK 314
             :|:     |.||..:: .|.|....:::..|       |..||..|....|.....:.:.|.|:
Zfish   287 RFLVLNPAKRGTLEQIMKERWINSGFEDDELK-------PFTEPDADISDQKRIDVIVGMGFSKE 344

  Fly   315 CLDKDPTK--------------RWSCEKLTKHSYFDDY-IAKQRELEHVNSLEAANLRQQQLASQ 364
            .:.:...|              |.:.|:::..|...:. :||.|....:||...::|:.|:..|.
Zfish   345 KIHESLFKMNYDEVTAIYLLLGRKTHEEVSDSSSNSNLSVAKTRPSSEMNSQSPSHLKVQRSISS 409

  Fly   365 QFMLATAAQQLQTGPAQAAAIAAARDKSKTSNTSLPLLPSTQ-------------HHHHPHQDYV 416
            .....:.....|.|       ..|.:....|...:|:...::             :|..|
Zfish   410 SESRKSRRHSEQVG-------VVANNALSNSKRVVPVTADSEVKQEGGVIARKLPNHSPP----- 462

  Fly   417 KLQPLNKNANLLHRTE 432
              .||..|||..::||
Zfish   463 --SPLLGNANNPNKTE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	88/332 (27%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	88/330 (27%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	75/253 (30%)
		UBA_like_SF	326..368	CDD:328731	5/41 (12%)
		MARK1-3_C	647..744	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910