DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and plk3

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_958465.1	Gene:	plk3 / 334202	ZFINID:	ZDB-GENE-030131-6134	Length:	644	Species:	Danio rerio

Alignment Length:	492	Identity:	118/492 - (23%)
Similarity:	177/492 - (35%)	Gaps:	112/492 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPDLVETRQYRPQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESE-DDPAIRKI 93
            :|:|.:.......|.|    |.|...||:|.:...|:..|.....:.|||...:|. ..|..|:.
Zfish    27 KPELAQVVVDAKTGRS----YCKGKLLGKGGFARCYEMTDLANNKMYAVKVIPQSRVSKPHQREK 87

  Fly    94 ALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHEL--ERHPQGCPEHLTKQICYQT 156
            .:.||.|.|:|:|.::|.....|..:..:::..|.|....|..:  .||....||  .:....|.
Zfish    88 IINEIELHKSLQHKHVVKFSHHFEDQDNIYIFLELCSRKSLAHIWKARHTLTDPE--VRYYLRQI 150

  Fly   157 LLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYV-ATRWYRAPELLVG 220
            :..:.|.|.:|.||||:|..|..:....:::|.|||.|..|...|.....: .|..|.|||:| .
Zfish   151 ISSLKYLHNKGILHRDLKLGNFFVNENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVL-N 214

  Fly   221 DTQYGTPVDVWAIGCLFAELVRG----EALWPGRSDVDQLYLIRKTLGDLLPRHI---------- 271
            ...:||..|||::||:...|:.|    |.|     |:.:.|...|.:...||..:
Zfish   215 RQGHGTESDVWSLGCVMYTLLCGNPPFETL-----DLKETYKCIKEVKYSLPSSLTPSAQKLISS 274

  Fly   272 -------------QIFGQNEYFKGITLPVPPTLEP--------LEDKMPAKSQQNPLTIDFLKKC 315
                         ||...:.:.||.|   |..|.|        |....|||.....:......|.
Zfish   275 ILQKNPCDRLTLDQILAHDYFTKGFT---PEKLPPSSCVMVPELNPPSPAKKFFTKMAKSLFGKK 336

  Fly   316 LDKDPTKRWSCEK---------LTKHSYFDDYIAKQRELEHVNSLEA----------------AN 355
            ..|...|..|.||         :.|||     |.:|...:.:...||                |.
Zfish   337 KSKTVEKTTSEEKDDISKLVSGMVKHS-----IGRQMSYKTMGVNEATSPTVQLASSGPLDTPAE 396

  Fly   356 LRQQQLASQQF--MLATAAQQLQTGPAQAAAIAAARDKSKTSNTSLPLLPSTQHHHHPHQDYVKL 418
            ...::.||:.|  .:|::.......|..:   |.|....|..|:.|..:| |...:.|  ..||.
Zfish   397 EESRKSASRSFKGTVASSTDGCDDIPTPS---AVAESAMKVLNSCLSSMP-TASRNPP--CLVKT 455

  Fly   419 QPL--------------------NKNANLLHRTEHHL 435
            :|.                    |:|..:|.....||
Zfish   456 KPFIWVTKWVDYSNKYGFGYQLSNQNVGVLFNEGTHL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	88/334 (26%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	88/332 (27%)
plk3	NP_958465.1	STKc_PLK3	41..295	CDD:271091	70/265 (26%)
		S_TKc	43..295	CDD:214567	69/259 (27%)
		POLO_box_1	457..545	CDD:240561	6/36 (17%)
		POLO_box_2	557..640	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910