DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and Cdkl1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001020292.1	Gene:	Cdkl1 / 314198	RGDID:	1305080	Length:	352	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	213/376 - (56%)
Similarity:	264/376 - (70%)	Gaps:	35/376 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVS 111
            |::|||:.::||||||||:|||:|:||.:||:|||:|:||||.|:||||||||:||.||||||||
  Rat     1 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNLVS 65

  Fly   112 LLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPE 176
            ||||||||||||||||:|..||||||:|:.:|.||.|.|.|.:|||..|.:|||..|:|||:|||
  Rat    66 LLEVFRRKRRLHLVFEYCHHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPE 130

  Fly   177 NILLTAQGQVKLCDFGFARMLS-PGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAEL 240
            |||:|....:|||||||||:|: ||:.|||||||||||:|||||||||||.|||||||||:||||
  Rat   131 NILITKHSVIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAEL 195

  Fly   241 VRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQN 305
            :.|..||||:||||||||||||||||:|||.|:|..|:||.|:.:|.|..:|.||.|.|..|..
  Rat   196 LSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDPEDMETLELKFPNISYS- 259

  Fly   306 PLTIDFLKKCLDKDPTKRWSCEKLTKHSYFDDYIAKQRELEHVNSLEA-ANLRQQQLASQQFMLA 369
              .:.|||.||..||.:|.:||:|.:|.|||. |....||...:.... ..|||    |::.:
  Rat   260 --ALGFLKGCLHMDPAERLTCEQLLQHPYFDS-IRDVGELARPHDKPTRKTLRQ----SRKHL-- 315

  Fly   370 TAAQQLQTGPAQAAAIAAARDKSKTSNTSLPLLPSTQHH--------HHPH 412
            |..|.|               ...||::.||.|...::|        |.|:
  Rat   316 TGLQHL---------------PQLTSSSVLPALDRKKYHCGTRNFNYHFPN 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	191/287 (67%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	191/285 (67%)
Cdkl1	NP_001020292.1	STKc_CDKL1_4	2..287	CDD:270837	191/287 (67%)
		Pkinase	4..287	CDD:278497	191/285 (67%)
		[NKR]KIAxRE	45..51		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	413	1.000	Domainoid score	I654
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55805
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1752
OMA	1	1.010	-	-		QHG52261
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	1	1.000	-	-		FOG0004639
OrthoInspector	1	1.000	-	-		oto98186
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980