DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and par-1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	90/361 - (24%)
Similarity:	154/361 - (42%)	Gaps:	84/361 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PDLVETRQYRPQGSSKMD-----------------RYEKLSRLGEGSYGVVYKCRDRETGALVAV 78
            |..::.|....:||..|.                 :|:.:..:|:|::..|...:...||..||:
  Fly   217 PSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAI 281

  Fly    79 KRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFC------ELTVLHEL 137
            |...:::.:|...:...||:|::|.|.|||:|.|.:|...::.|:|:.|:.      :..|||
  Fly   282 KIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLH-- 344

  Fly   138 ERHPQGCPEHLTKQICY-QTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGE 201
                 |..:....::.: |.:..|.|||::..:|||:|.||:||.::..:|:.||||:...:||.
  Fly   345 -----GRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGS 404

  Fly   202 NYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDL 266
            ....:..:..|.||||..|....|..||||::|.:...||.|.
  Fly   405 KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGS---------------------- 447

  Fly   267 LPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTI-----DFLKKCLDKDPTKRWSC 326
            ||           |.|      .||..|.:::.....:.|..:     :.|:|.|..:|.||.|.
  Fly   448 LP-----------FDG------STLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASL 495

  Fly   327 EKLTKHSY----FDD-----YIAKQRELEHVNSLEA 353
            |.:....:    |::     ||..:.:|.....:||
  Fly   496 ETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEA 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	79/319 (25%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	79/300 (26%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	79/297 (27%)
		S_TKc	253..504	CDD:214567	79/296 (27%)
		UBA_MARK_Par1	525..563	CDD:270522	2/7 (29%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910