DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and Eif2ak2

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	XP_006523926.1	Gene:	Eif2ak2 / 19106	MGIID:	1353449	Length:	529	Species:	Mus musculus

Alignment Length:	361	Identity:	97/361 - (26%)
Similarity:	149/361 - (41%)	Gaps:	63/361 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FHSSSFY----LPQSLQNSFLYRLI---------QKIQVCNEPDLVETRQYRPQGSSKMDRYEKL 53
            |.|||..    :.||...||....:         :|..|...||.|:..:|........| :|.:
Mouse   196 FSSSSSMTSNGVSQSAPGSFSSENVFTNGLGENKRKSGVKVSPDDVQRNKYTLDARFNSD-FEDI 259

  Fly    54 SRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLV-------- 110
            ..:|.|.:|.|:|.:.|..|...|:||...:.:.      |..|::.|..|.|.|:|
Mouse   260 EEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEK------AEHEVQALAELNHVNIVQYHSCWEG 318

  Fly   111 -------SLLEVFRRKRR-LHLVFEFCELTVLHE--LERHPQGCPEHLTKQICYQTLLGVAYCHK 165
                   |:.:..|.|.| |.:..|||:...|.:  ..|:.....:.|...:..|.:.||.|.|.
Mouse   319 VDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHS 383

  Fly   166 QGCLHRDIKPENILLTAQGQVKLCDFGFARML-SPGENYTDYVATRWYRAPELLVGDTQYGTPVD 229
            :|.:|||:||.||.|..:..:|:.|||.|..| :.|::.|....|..|.:||.|. ...||..||
Mouse   384 KGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLF-LKHYGKEVD 447

  Fly   230 VWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPL 294
            ::|:|.:.|||:  ...:.....:.....:||  ||.   ...||...|  |.:          |
Mouse   448 IFALGLILAELL--HTCFTESEKIKFFESLRK--GDF---SNDIFDNKE--KSL----------L 493

  Fly   295 EDKMPAKSQQNPLTIDFLKKCLD----KDPTKRWSC 326
            :..:..|.:..|.|.:.||...:    .:..||.:|
Mouse   494 KKLLSEKPKDRPETSEILKTLAEWRNISEKKKRNTC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	83/302 (27%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	82/300 (27%)
Eif2ak2	XP_006523926.1	DSRM_EIF2AK2_rpt1	21..88	CDD:380732
		DSRM_EIF2AK2_rpt2	108..175	CDD:380733
		PKc_like	249..514	CDD:389743	80/291 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910