DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and cdkl-1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001256289.1	Gene:	cdkl-1 / 189841	WormBaseID:	WBGene00012779	Length:	484	Species:	Caenorhabditis elegans

Alignment Length:	371	Identity:	197/371 - (53%)
Similarity:	258/371 - (69%)	Gaps:	15/371 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPQSLQNSFLYRLIQKIQVCNEPDLVETRQYRPQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETG 73
            |.::..:..::..|:.:.|.........|....:....||:|::||:||||||||||||::|:||
Worm    94 LEKTKSDDMVFAEIEALTVMENNLFCSLRNSSKRRCEAMDKYDRLSKLGEGSYGVVYKCKNRDTG 158

  Fly    74 ALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELE 138
            .:||:|:|||:||||.|:||||||||:||.|||.|||.|:|||:|.|:||||||.|:.|||||||
Worm   159 QIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNLVGLIEVFKRNRKLHLVFELCDRTVLHELE 223

  Fly   139 RHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENY 203
            ::|.|..:.|.|:|.||.|..:.:||...|:|||:|||||.||...||||.||||||:::..|.|
Worm   224 KNPHGVNDELIKKIIYQLLEALKFCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARIINTTEMY 288

  Fly   204 TDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLP 268
            ||||||||||:|||||||.|||.|||:||:||::|||:.||||||||||:||||.||||||:.||
Worm   289 TDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLP 353

  Fly   269 RHIQIFGQNEYFKGITLPVPPTLEPLEDKMP-AKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKH 332
            |||.||..|::|.|:::|.|..||||..|:| |.|.|    :|||:||.:..|.:|:||.:|..|
Worm   354 RHISIFRTNQFFFGLSIPEPEHLEPLPSKLPNASSAQ----LDFLQKCFEMSPDRRFSCSELMLH 414

  Fly   333 SYFDDYIAKQRELEHV----------NSLEAANLRQQQLASQQFML 368
            ..|.::|.:.|:.|..          |.|...|.....|.|:.|.|
Worm   415 GIFSNWILRIRQDESTPTGLTSKRSPNYLPLLNGNSNNLVSKNFSL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	181/287 (63%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	180/285 (63%)
cdkl-1	NP_001256289.1	STKc_CDKL1_4	133..417	CDD:270837	181/287 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156149
Domainoid	1	1.000	388	1.000	Domainoid score	I417
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55805
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1093
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52261
OrthoDB	1	1.010	-	-		D398098at2759
OrthoFinder	1	1.000	-	-		FOG0004639
OrthoInspector	1	1.000	-	-		oto17755
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3077
SonicParanoid	1	1.000	-	-		X3254
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940