DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and mig-15

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001024973.1	Gene:	mig-15 / 181248	WormBaseID:	WBGene00003247	Length:	1096	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	119/481 - (24%)
Similarity:	190/481 - (39%)	Gaps:	117/481 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NEPDLVETRQYRPQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKI 93
            :|.||...|.  |.|.     :|.:..:|.|:||.|||.|..:|..|.|:|....:||:....|:
Worm     7 DEIDLNSLRD--PAGI-----FELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEEDEIKL 64

  Fly    94 ALREIRLL-KNLKHPNLVSLLEVFRRK--------RRLHLVFEFCELTVLHELERHPQG--CPEH 147
               ||.:| |:..|.|:.:....|.:|        .:|.||.|||....:.:|.::.:|  ..|.
Worm    65 ---EINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEE 126

  Fly   148 LTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARML--SPGENYTDYVATR 210
            ....||.:.|.|:.:.|:...:|||||.:|:|||...:|||.|||.:..|  :.|...| ::.|.
Worm   127 WIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNT-FIGTP 190

  Fly   211 WYRAPELLVGD----TQYGTPVDVWAIGCLFAELVRGEA----LWPGRSDVDQLYLIRKTLGDLL 267
            ::.|||::..|    ..|.:..|:|::|....|:..|..    :.|.|:    |:||.:.....|
Worm   191 YWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRA----LFLIPRNPPPKL 251

  Fly   268 PRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKH 332
            .|:.:...:.|.|             :|..:.....|.|.|...|:....|:...    |:..:|
Worm   252 KRNKKWTKKFETF-------------IETVLVKDYHQRPYTGALLRHPFIKEQPH----EQTIRH 299

  Fly   333 SYFDDYIAKQR-------ELEHVNSLE---AANLR--------------------------QQQL 361
            | ..::|.:.|       :.|:..|.:   :.|.|                          |:..
Worm   300 S-IKEHIDRNRRVKKDDADYEYSGSEDDEPSPNNRGPSMGIRDDSESSSMIPMDNTLRKGFQKLQ 363

  Fly   362 ASQQFMLATAAQQLQTGPAQAA------------------------AIAA--ARDKSKTSNTSLP 400
            .|.:......||||:..|.|.|                        |:::  |.|..:.|..|.|
Worm   364 ESSRGFAEPGAQQLRRLPQQPAPAPFQYQQSRYVEPRRESSEVKLRAVSSRGAADGPRHSPASRP 428

  Fly   401 LLPSTQHHHHPHQDYVKLQPLNKNAN 426
             .|.:.|...|.|.:.....|...||
Worm   429 -RPVSHHQRSPQQSHPAAPHLADLAN 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	85/307 (28%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	85/305 (28%)
mig-15	NP_001024973.1	STKc_myosinIII_N_like	14..288	CDD:270785	84/301 (28%)
		S_TKc	21..288	CDD:214567	81/287 (28%)
		CNH	773..1076	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910