DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and par-1

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001122967.2	Gene:	par-1 / 179912	WormBaseID:	WBGene00003916	Length:	1216	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	105/464 - (22%)
Similarity:	190/464 - (40%)	Gaps:	97/464 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLL 113
            :|:.|..:|:|::..|...:...||..||:|...::..:|:..:...||::::|.|.|||:|.|.
Worm   105 KYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLY 169

  Fly   114 EVFRRKRRLHLVFEFCE-LTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPEN 177
            :|...::.|:||.|:.. ..|...|..|.: ..|...:....|.:..|.|.|.:..:|||:|.||
Worm   170 QVMETEQTLYLVLEYASGGEVFDYLVAHGR-MKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAEN 233

  Fly   178 ILLTAQGQVKLCDFGFARMLSPGENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVR 242
            :||.....:|:.||||:...|.|.....:..:..|.||||..|....|..||||::|.:...||.
Worm   234 LLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVS 298

  Fly   243 GEALWPGR---------------------SDVDQL---YLI-----RKTLGDLL-PRHIQIFGQN 277
            |...:.|:                     :|.:.|   :|:     |.:|.::: .|.:.:..::
Worm   299 GSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMNVGYED 363

  Fly   278 EYFKGITLPVPPTLEPLEDKMPAKSQQNPLTI---DFLKKCL----------------------- 316
            :..|       |.:||.:|::..:..:..:.|   .|.|..:
Worm   364 DELK-------PFIEPPKDQIDEQRIEKLIQIFQLGFNKAAILESVEKEKFEDIHATYLLLGERK 421

  Fly   317 -DKDPTKRWSCEKLTKHSYFD------DYIAKQRELEHVNSLEAAN--------LRQQQLASQQF 366
             |.|.::....:.|..||..:      .:.|.....|||.|..|:.        .|....|:...
Worm   422 SDMDASEITMAQSLLSHSSINVSSSLGQHPAGVITREHVTSSSASGSSASPSRYSRSSATATGAS 486

  Fly   367 M-----LATAA-----QQLQTGPAQAAAI---AAARDKSKTSNTSLPLLPSTQHHHHPHQDYVKL 418
            :     ||:||     ||....|:..::.   ::..|.:.|:.....::..|:|    ....::.
Worm   487 ITAGSALASAANAQKHQQSSAAPSSGSSSSRRSSQNDAAATAAGGTVVMSGTRH----GGVQMRA 547

  Fly   419 QPLNKNANL 427
            ||.::.|.:
Worm   548 QPTSRQATI 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	83/343 (24%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	83/342 (24%)
par-1	NP_001122967.2	STKc_MARK	105..357	CDD:270974	70/252 (28%)
		S_TKc	106..357	CDD:214567	70/251 (28%)
		MARK1-3_C	1117..1214	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910