DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and Plk3

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_038835.2	Gene:	Plk3 / 12795	MGIID:	109604	Length:	648	Species:	Mus musculus

Alignment Length:	317	Identity:	87/317 - (27%)
Similarity:	133/317 - (41%)	Gaps:	47/317 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NEPD-LVETRQYRPQGSSKMD-----RYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESE-D 86
            :||: |...|...|.|....|     .|.|...||:|.:...|:..|.|:|...|||...:|. .
Mouse    36 SEPEVLAGPRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVA 100

  Fly    87 DPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHEL--ERHPQGCPEHLT 149
            .|..|:..|.||.|.::|:|.::|.....|.....:::..|.|....|..:  .||....||  .
Mouse   101 KPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE--V 163

  Fly   150 KQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYTDYV-ATRWYR 213
            :....|.|.|:.|.|::|.||||:|..|..:|...::|:.|||.|..|.|.|.....: .|..|.
Mouse   164 RYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYV 228

  Fly   214 APELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNE 278
            |||:|:.. .:|...|||::||:...|:.|...:. .:|:.:.|...|.:...||..:
Mouse   229 APEVLLRQ-GHGPEADVWSLGCVMYTLLCGSPPFE-TADLKETYRCIKQVHYTLPASL------- 284

  Fly   279 YFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKHSYF 335
                              .:||:        ..|...|...|..|.|.|::.:|.:|
Mouse   285 ------------------SLPAR--------QLLAAILRASPRDRPSIEQILRHDFF 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	80/295 (27%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	79/288 (27%)
Plk3	NP_038835.2	STKc_PLK3	61..315	CDD:271091	79/290 (27%)
		S_TKc	63..315	CDD:214567	79/288 (27%)
		POLO_box_1	462..550	CDD:240561
		POLO_box_2	563..630	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910