DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and Cdk9

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_570930.1	Gene:	Cdk9 / 107951	MGIID:	1328368	Length:	372	Species:	Mus musculus

Alignment Length:	313	Identity:	105/313 - (33%)
Similarity:	167/313 - (53%)	Gaps:	35/313 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLV 110
            ::.:||||:::|:|::|.|:|.:.|:||..||:|:.:...:.......|||||::|:.|||.|:|
Mouse    15 EVTKYEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79

  Fly   111 SLLEVFRRKR--------RLHLVFEFCELTVLHELERHPQGCPEHLT----KQICYQTLLGVAYC 163
            :|:|:.|.|.        .::|||:|||    |:|...........|    |::....|.|:.|.
Mouse    80 NLIEICRTKASPYNRCKGSIYLVFDFCE----HDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140

  Fly   164 HKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGEN-----YTDYVATRWYRAPELLVGDTQ 223
            |:...||||:|..|:|:|..|.:||.|||.||..|..:|     ||:.|.|.|||.||||:|:..
Mouse   141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERD 205

  Fly   224 YGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPR------HIQIFGQNEYFKG 282
            ||.|:|:|..||:.||:.....:..|.::..||.||.:..|.:.|.      ..::|.:.|..||
Mouse   206 YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKG 270

  Fly   283 ITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKHSYF 335
                   ....::|::.| ..::|..:|.:.|.|..||.:|...:....|.:|
Mouse   271 -------QKRKVKDRLKA-YVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	104/309 (34%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	104/307 (34%)
Cdk9	NP_570930.1	STKc_CDK9	6..315	CDD:270848	104/311 (33%)
		T-loop. /evidence=ECO:0000250	166..191		10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910