DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and BUB1B-PAK6

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001122100.1	Gene:	BUB1B-PAK6 / 106821730	HGNCID:	52276	Length:	681	Species:	Homo sapiens

Alignment Length:	342	Identity:	93/342 - (27%)
Similarity:	157/342 - (45%)	Gaps:	56/342 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSSFYLPQSLQNSFLYRLIQKIQVCNEPDLVET--------RQYRPQGSSK--MDRYEKLSRLGE 58
            :|:.||||.       ..:.|..:..|...|.|        |....||..:  :|.|.|   :||
Human   361 TSNLYLPQD-------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVK---IGE 415

  Fly    59 GSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLH 123
            ||.|:|...|::.:|..||||.....:...  |::...|:.::::.:|.|:|.:.:.:.....|.
Human   416 GSTGIVCLAREKHSGRQVAVKMMDLRKQQR--RELLFNEVVIMRDYQHFNVVEMYKSYLVGEELW 478

  Fly   124 LVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKL 188
            ::.||.:...|.::....:...|.:. .:|...|..:||.|.||.:|||||.::||||..|:|||
Human   479 VLMEFLQGGALTDIVSQVRLNEEQIA-TVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542

  Fly   189 CDFGFARMLSPG-ENYTDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSD 252
            .||||...:|.. ......|.|.::.||| ::..:.|.|.||:|::|.:..|:|.||..:...|.
Human   543 SDFGFCAQISKDVPKRKSLVGTPYWMAPE-VISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSP 606

  Fly   253 VDQLYLIRKTLGDLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLD 317
            |..:..:|.:                         ||      .|:....:.:|:..|||::.|.
Human   607 VQAMKRLRDS-------------------------PP------PKLKNSHKVSPVLRDFLERMLV 640

  Fly   318 KDPTKRWSCEKLTKHSY 334
            :||.:|.:.::|..|.:
Human   641 RDPQERATAQELLDHPF 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	81/288 (28%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	80/286 (28%)
BUB1B-PAK6	NP_001122100.1	PBD	11..67	CDD:307091
BUB1B-PAK6	NP_001122100.1	STKc_PAK6	385..681	CDD:270821	85/311 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910