DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and PAK4

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001014831.1	Gene:	PAK4 / 10298	HGNCID:	16059	Length:	591	Species:	Homo sapiens

Alignment Length:	319	Identity:	92/319 - (28%)
Similarity:	145/319 - (45%)	Gaps:	56/319 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPDLVETRQYR-----------PQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVE 83
            ||..|...|:|           |:  |.:|.:.|   :||||.|:|.....|.:|.|||||:...
Human   295 EPQRVSHEQFRAALQLVVDPGDPR--SYLDNFIK---IGEGSTGIVCIATVRSSGKLVAVKKMDL 354

  Fly    84 SEDDPAIRKIALREIRLLKNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHPQGCPEHL 148
            .:...  |::...|:.::::.:|.|:|.:...:.....|.:|.||.|...|.::..|.:...|.:
Human   355 RKQQR--RELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI 417

  Fly   149 TKQICYQTLLGVAYCHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLS---PGENYTDYVATR 210
            . .:|...|..::..|.||.:|||||.::||||..|:|||.||||...:|   |...  ..|.|.
Human   418 A-AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRK--SLVGTP 479

  Fly   211 WYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFG 275
            ::.||| |:....||..||:|::|.:..|:|.||..:.....:..:.:||..|
Human   480 YWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------ 531

  Fly   276 QNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRWSCEKLTKHSY 334
                        ||.|:.|....|:..       .||.:.|.:||.:|.:..:|.||.:
Human   532 ------------PPRLKNLHKVSPSLK-------GFLDRLLVRDPAQRATAAELLKHPF 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	85/290 (29%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	84/288 (29%)
PAK4	NP_001014831.1	CRIB_PAK_like	10..55	CDD:238526
		Linker	25..320		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..301		3/5 (60%)
		GEF-interaction domain (GID)	298..323		5/26 (19%)
		STKc_PAK4	300..591	CDD:132988	89/314 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910