DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7236 and HIPK3

DIOPT Version :9

Sequence 1:	NP_608950.3	Gene:	CG7236 / 33798	FlyBaseID:	FBgn0031730	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_005725.3	Gene:	HIPK3 / 10114	HGNCID:	4915	Length:	1215	Species:	Homo sapiens

Alignment Length:	431	Identity:	108/431 - (25%)
Similarity:	175/431 - (40%)	Gaps:	104/431 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YRLIQKIQVCNEPDLVETRQYRPQGSSKMDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVE 83
            |:|:|...:|                |..:.||.|..||.|::|.|.||..|.|..:||:|..
Human   182 YQLVQHEVLC----------------SMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKIL-- 228

  Fly    84 SEDDPAIRKIALREIRLL-----KNLKHPNLVSLLEVFRRKRRLHLVFEFCELTVLHELERHP-Q 142
             ::.|:..:....|:.:|     :|....|.|...|.|:.:....||||..|..:...|:::. .
Human   229 -KNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFS 292

  Fly   143 GCPEHLTKQICYQTLLGVAYCHKQGCLHRDIKPENILLT----AQGQVKLCDFGFARMLSPGENY 203
            ..|..:.:.|..|....:......|.:|.|:|||||:|.    ...:||:.|||.|..:|.....
Human   293 PLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357

  Fly   204 TDYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLP 268
            | |:.:|:|||||:::| ..:...:|:|::||:.|||..|..|:||..:.||:..|.:|.|
Human   358 T-YLQSRYYRAPEIILG-LPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQG---- 416

  Fly   269 RHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPT-KRWSCEKLTKH 332
                                         :|.:...|..|......|.:.|.: ..|..:.|.:|
Human   417 -----------------------------LPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEH 452

  Fly   333 SYFDDYIAKQR---------ELEHVNS---LEAANLRQQQLASQQF------MLATAAQQLQTGP 379
            .......:|:.         ::.|||:   ||.::|..::...::|      ||...| .|:..|
Human   453 EAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDA-DLRITP 516

  Fly   380 AQAAAIAAARDKSKTSNTSLPLLPSTQHHH---HPHQDYVK 417
            |:            |.|.     |.....|   .||.::||
Human   517 AE------------TLNH-----PFVNMKHLLDFPHSNHVK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7236	NP_608950.3	STKc_CDKL1_4	48..335	CDD:270837	81/297 (27%)
CG7236	NP_608950.3	Pkinase	50..335	CDD:278497	81/295 (27%)
HIPK3	NP_005725.3	STKc_HIPK3	196..525	CDD:271131	98/384 (26%)
		S_TKc	197..525	CDD:214567	98/383 (26%)
		Interaction with AR. /evidence=ECO:0000250	767..944
		Interaction with FAS. /evidence=ECO:0000250	796..891
		Required for localization to nuclear speckles. /evidence=ECO:0000250	855..1011
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	866..918
		Interaction with UBL1. /evidence=ECO:0000305	870..880
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910