DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and CCT3

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_012520.1	Gene:	CCT3 / 853438	SGDID:	S000003551	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	574	Identity:	125/574 - (21%)
Similarity:	233/574 - (40%)	Gaps:	93/574 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDK 89
            |.:::...|.:.:...:.....:||.:...:|||....::....|...:|.||..:.:.|.:
Yeast     9 NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDV--- 70

  Fly    90 FQNIGAKLVQDVANNTNEEAGDGTTTATVLA-RAIAKEGFEKISRGASPVEIRRGVMLAIETVKD 153
             .:..||.:.:::...:||.||||||..:|| ..:|:.....|.:...||.|.:.:..|:....:
Yeast    71 -AHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALE 134

  Fly   154 NLRRLSRPVNTPEEICQVATISAN-GDKSVGNLISEAIKKVGRDGVITV-KD-GKTLCDE----- 210
            .::::|:||:...:......|.|: |.|.|.:. ||.:.::..|.|.|| || |:|:..|
Yeast   135 VIKQVSKPVDVENDAAMKKLIQASIGTKYVIHW-SEKMCELALDAVKTVRKDLGQTVEGEPNFEI 198

  Fly   211 ------------------LEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSI 257
                              ..|::|:..::..:.|......:..:|...|..|.:  ||.:|..:|
Yeast   199 DIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVLLDCPLEY--KKGESQTNI 261

  Fly   258 VPALELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGG 322
              .:|......:.|.|..|.::......|.|....|      :...|..|..:..|:     .||
Yeast   262 --EIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLV------ITEKGVSDLAQHYLL-----KGG 313

  Fly   323 IVFGDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEK 387
            ...        |..:|.||..|:..|.              .|.:..|||.|:|:...:.....|
Yeast   314 CSV--------LRRVKKSDNNRIARVT--------------GATIVNRVEDLKESDVGTNCGLFK 356

  Fly   388 EKM--QERLARLSS-----GVALLRVGGSSDVEVSEKKDRVIDALNATR-AAVEEGIVPGGG--- 441
            .:|  .|..:.|.:     ...::..|||.|: ::|....:.||:...| ..:...:.||||
Yeast   357 VEMIGDEYFSFLDNCKEPKACTIMLRGGSKDI-LNEIDRNLQDAMAVARNVMLSPSLSPGGGATE 420

  Fly   442 -TALLRCIQKLNDLKGANEDQNMGIEIIRRALRMPCL--TIAKNAGVDGAMVVAKVEI--LDGDY 501
             ...::..:|...|:|..:.....:     |..|.|:  |:.:|||.|...:::::..  ..|::
Yeast   421 MAVSVKLAEKAKQLEGIQQWPYQAV-----ADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQGNF 480

  Fly   502 --GYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEE 553
              |.|..||:..:|:..||.:|..:.:.::..|...|.||...:.:|:.:..:|
Yeast   481 TTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	124/572 (22%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	123/564 (22%)
CCT3	NP_012520.1	chap_CCT_gamma	4..533	CDD:274085	124/571 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810