DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and Cpn60beta3

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001032083.1	Gene:	Cpn60beta3 / 835751	AraportID:	AT5G56500	Length:	597	Species:	Arabidopsis thaliana

Alignment Length:	559	Identity:	250/559 - (44%)
Similarity:	370/559 - (66%)	Gaps:	17/559 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RYTNTLQRTAKISHVLWAR--NYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSW 68
            |..:..||.|:...:..|:  ::.||   |..::.:. .||:.|||.|.||:|||||||::|..:
plant    35 RTQSIAQRKARFPKIYAAKQLHFNKD---GTAIKKLQ-AGVNKLADLVGVTLGPKGRNVVLESKY 95

  Fly    69 GSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISR 133
            |||:|..||||||:.:.|:|..:|||||||:..|:.||:.|||||||:.|||:.:..||.:.::.
plant    96 GSPRIVNDGVTVAREVELEDPVENIGAKLVRQAASKTNDLAGDGTTTSVVLAQGLIAEGVKVVAA 160

  Fly   134 GASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGRDGV 198
            ||:||.|.||:....:.:...|:::|:.|. ..|:..||.:||..:..|||:|:||:.||||.||
plant   161 GANPVLITRGIEKTTKALVAELKKMSKEVE-DSELADVAAVSAGNNYEVGNMIAEAMAKVGRKGV 224

  Fly   199 ITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALEL 263
            :|:::||:..:.|.|:|||:||||||||||:..|:....|:::..|...:|||.:|..|:..||.
plant   225 VTLEEGKSAENSLYVVEGMQFDRGYISPYFVTDSEKMCAEYENCKLFLVDKKITNARDIISILED 289

  Fly   264 ANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDE 328
            |.....||:|||||:|.|.|:|||||:|:..::|.|:||||||:.:.:.|.|:|..||..|..:|
plant   290 AIKGGYPLLIIAEDIEQEPLATLVVNKLRGTIKVAALKAPGFGERKSQYLDDIAALTGATVIREE 354

  Fly   329 ANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAE-VEKRVEGLREAIKESTSSYEKEKMQE 392
            ..: :||.:.....|..|:||::||.|.:: |.|...| |:||||.::..|:.:...|||||:.|
plant   355 VGL-QLEKVGPEVLGNAGKVVLTKDTTTIV-GDGSTEEVVKKRVEQIKNLIEAAEQDYEKEKLNE 417

  Fly   393 RLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQKLNDLKG- 456
            |:|:||.|||:::||..::.|:.|||.||.||||||:||||||||.|||..|||...|::.:|.
plant   418 RIAKLSGGVAVIQVGAQTETELKEKKLRVEDALNATKAAVEEGIVVGGGCTLLRLASKVDAIKET 482

  Fly   457 -ANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGD---YGYDALKGEYGNMIERG 517
             ||:::.:|.:|:::||..|...|||||||:|::|..||  |..|   :||:|..|:|.:::..|
plant   483 LANDEEKVGADIVKKALSYPLKLIAKNAGVNGSVVSEKV--LSSDNPKHGYNAATGKYEDLMAAG 545

  Fly   518 IIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAA 556
            |||||||||..:..|:.||.....::.||.|:...|:||
plant   546 IIDPTKVVRCCLEHASSVAKTFLMSDCVVVEIKEPESAA 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	243/537 (45%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	241/525 (46%)
Cpn60beta3	NP_001032083.1	PLN03167	1..597	CDD:215611	250/559 (45%)
Cpn60beta3	NP_001032083.1	groEL	51..597	CDD:237231	246/543 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780