DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and HSP60

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_189041.1	Gene:	HSP60 / 821983	AraportID:	AT3G23990	Length:	577	Species:	Arabidopsis thaliana

Alignment Length:	576	Identity:	328/576 - (56%)
Similarity:	437/576 - (75%)	Gaps:	11/576 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRYTNTLQRTAKI--------SHVLWARNY-AKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKG 59
            |:|:.:.|...|:|        |.:.|:||| ||:::||.|.||:||:||:.|||||.|||||||
plant     1 MYRFASNLASKARIAQNARQVSSRMSWSRNYAAKEIKFGVEARALMLKGVEDLADAVKVTMGPKG 65

  Fly    60 RNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIA 124
            |||:||||||:||:|||||||||||..|||.:|:||.||:.|||.||:.||||||.||||.|||.
plant    66 RNVVIEQSWGAPKVTKDGVTVAKSIEFKDKIKNVGASLVKQVANATNDVAGDGTTCATVLTRAIF 130

  Fly   125 KEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEA 189
            .||.:.::.|.:.:::|||:.:|::.|..||:..:|.::|.|||.||.||||||::.:|.||::|
plant   131 AEGCKSVAAGMNAMDLRRGISMAVDAVVTNLKSKARMISTSEEIAQVGTISANGEREIGELIAKA 195

  Fly   190 IKKVGRDGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSA 254
            ::|||::||||::|||||.:||||:||||.||||.|||||...|..|.|..|.|:|..||||.|.
plant   196 MEKVGKEGVITIQDGKTLFNELEVVEGMKLDRGYTSPYFITNQKTQKCELDDPLILIHEKKISSI 260

  Fly   255 PSIVPALELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVA 319
            .|||..||||..:::||:|::||:|::||:||::|:|:.|::|||:||||||:|||.||.|:|..
plant   261 NSIVKVLELALKRQRPLLIVSEDVESDALATLILNKLRAGIKVCAIKAPGFGENRKANLQDLAAL 325

  Fly   320 TGGIVFGDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSS 384
            |||.|..||..| .||.:.:|..|...:|.||||||::|.|.|.|..:|:|.|.:|.||:.|||.
plant   326 TGGEVITDELGM-NLEKVDLSMLGTCKKVTVSKDDTVILDGAGDKKGIEERCEQIRSAIELSTSD 389

  Fly   385 YEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQ 449
            |:|||:|||||:||.|||:|::||:|:.||.||||||.||||||:|||||||:||||.|||...:
plant   390 YDKEKLQERLAKLSGGVAVLKIGGASEAEVGEKKDRVTDALNATKAAVEEGILPGGGVALLYAAR 454

  Fly   450 KLNDLKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDG-DYGYDALKGEYGNM 513
            :|..|..||.||.:|::||:.||:.|..|||.||||:||::|.|:...|. |.||||.||||.:|
plant   455 ELEKLPTANFDQKIGVQIIQNALKTPVYTIASNAGVEGAVIVGKLLEQDNPDLGYDAAKGEYVDM 519

  Fly   514 IERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAAAGAAAGLGALGGM 569
            ::.|||||.||:|||:.|||.|:|||||.||||.:||.:|:.:..|.||:|.:|||
plant   520 VKAGIIDPLKVIRTALVDAASVSSLLTTTEAVVVDLPKDESESGAAGAGMGGMGGM 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	313/531 (59%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	307/520 (59%)
HSP60	NP_189041.1	GroEL	34..554	CDD:239460	307/520 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	580	1.000	Domainoid score	I40
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	652	1.000	Inparanoid score	I167
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		mtm993
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840