DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and HSP60-3A

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_566466.1	Gene:	HSP60-3A / 820599	AraportID:	AT3G13860	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	553	Identity:	293/553 - (52%)
Similarity:	401/553 - (72%)	Gaps:	11/553 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRYTNTL--------QRTAKISHVLWARNY-AKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKG 59
            |:|..:.|        .|......::.:||| |||:.||...||.|||||..:|:||.|||||||
plant     1 MYRVLSKLSSSIGSSTSRKLVSGRIISSRNYAAKDISFGIGARAAMLQGVSEVAEAVKVTMGPKG 65

  Fly    60 RNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIA 124
            ||||||.|:|.||||||||||||||:.:.|.:||||:||:.||:.||:.||||||.||||.:||.
plant    66 RNVIIESSYGGPKITKDGVTVAKSISFQAKAKNIGAELVKQVASATNKVAGDGTTCATVLTQAIL 130

  Fly   125 KEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEA 189
            .||.:.::.|.:.:::|.|:.:||..|..:|:..:..::|||||.|||||||||::.:|.||:.|
plant   131 IEGCKSVAAGVNVMDLRVGINMAIAAVVSDLKSRAVMISTPEEITQVATISANGEREIGELIARA 195

  Fly   190 IKKVGRDGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSA 254
            ::|||::|||||.||.||.:||||:||||..|||||||||...|..|.|.::.::|..||||...
plant   196 MEKVGKEGVITVADGNTLDNELEVVEGMKLARGYISPYFITDEKTQKCELENPIILIHEKKISDI 260

  Fly   255 PSIVPALELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVA 319
            .|::..||.|....:||:|:|||:|::||:.|::|:...||:|||:||||||||||.:|.|:||.
plant   261 NSLLKVLEAAVKSSRPLLIVAEDVESDALAMLILNKHHGGLKVCAIKAPGFGDNRKASLDDLAVL 325

  Fly   320 TGGIVFGDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSS 384
            ||..|..:|..: .||.|:....|...:|.|::|||::|.|.|.|..:|:|.|.||.|.::|||:
plant   326 TGAEVISEERGL-SLEKIRPELLGTAKKVTVTRDDTIILHGGGDKKLIEERCEELRSANEKSTST 389

  Fly   385 YEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQ 449
            :::||.||||::||.|||:.:|||:|:.||.|:||||.||||||||||||||:||||.|||...:
plant   390 FDQEKTQERLSKLSGGVAVFKVGGASESEVGERKDRVTDALNATRAAVEEGIIPGGGVALLYATK 454

  Fly   450 KLNDLKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAK-VEILDGDYGYDALKGEYGNM 513
            .|::|:..||||..|::|::.||:.|..|||.|||.||::||.| :|..|.::|:||.||:|.:|
plant   455 ALDNLQTENEDQRRGVQIVQNALKAPAFTIAANAGYDGSLVVGKLLEQDDCNFGFDAAKGKYVDM 519

  Fly   514 IERGIIDPTKVVRTAISDAAGVASLLTTAEAVV 546
            ::.|||||.||:|||::|||.|:.||||.||.|
plant   520 VKAGIIDPVKVIRTALTDAASVSLLLTTTEASV 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	289/526 (55%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	285/520 (55%)
HSP60-3A	NP_566466.1	PTZ00114	20..570	CDD:185455	289/534 (54%)
HSP60-3A	NP_566466.1	GroEL	34..552	CDD:239460	284/518 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	580	1.000	Domainoid score	I40
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	652	1.000	Inparanoid score	I167
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		mtm993
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840