Protein Alignment Hsp60C and TCP1

DIOPT Version :10

• Sequence 1: NP_608948.2
• Gene: Hsp60C / 33796
• FlyBaseID: FBgn0031728
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_110379.2
• Gene: TCP1 / 6950
• HGNCID: 11655
• Length: 556
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 126/582 - (21%)
• Similarity: 228/582 - (39%)
• Gaps: 127/582 - (21%)

  Fly    33 GPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKL 97
            |..:|:..:.....:|:.|..::||.|.:.::....|...||.||.|:.|.:    :.::..||:
Human    14 GETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLL----EVEHPAAKV 74

  Fly    98 VQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVML----AIETVKDNL--- 155
            :.::|:..::|.|||||:..::|..:.|...|.:.:...|..:..|..|    |:..:.:||
Human    75 LCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIVN 139

  Fly   156 -RRLSRP--VNTPEEICQVATISANGDKSVGNLISEAIKKVGRDGV------------ITVKDGK 205
             ..|.|.  :|..:.......|..||| ...|::.:|:..:....:            |....|:
Human   140 TDELGRDCLINAAKTSMSSKIIGINGD-FFANMVVDAVLAIKYTDIRGQPRYPVNSVNILKAHGR 203

  Fly   206 TLCDELEVIEGMKFDRGYISPYFINTSKG----------AKVEFQDALLLFCEKKIKSAPSIVPA 260
            :..:.:           .||.|.:|...|          ||:...|..|...:.|:.....|...
Human   204 SQMESM-----------LISGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDP 257

  Fly   261 LELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGL------QVCA---VKAPGFGDNR--KENLM 314
            .:|...:::     ..|:..|.:..::.....|.|      .:|.   |:|......|  |.:|.
Human   258 EKLDQIRQR-----ESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLK 317

  Fly   315 DMAVATGGIVFGDEANMVRLEDIKMSDFGRVGEVVVSK--DDTMLLKGKGQKAEVEKRVEGLREA 377
            .:|.|:|..:....||:...|..:.:..|:..|||..:  ||.::|
Human   318 RIAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDELIL------------------- 363

  Fly   378 IKESTSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVE-EGIVPGGG 441
            ||.:.            ||.|:.: :||  |::|....|.:..:.|||...:..:| :.:|||||
Human   364 IKNTK------------ARTSASI-ILR--GANDFMCDEMERSLHDALCVVKRVLESKSVVPGGG 413

  Fly   442 ---TALLRCIQKLNDLKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGD--- 500
               .||...::......|:.|  .:.|....|:|.:...|:|.||..|...:|||:.....:
Human   414 AVEAALSIYLENYATSMGSRE--QLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQV 476

  Fly   501 ---------YGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEE 553
                     .|.|...|:..:..:.|:.:|| :|:        |.||....||.:|.|.:::
Human   477 NPERKNLKWIGLDLSNGKPRDNKQAGVFEPT-IVK--------VKSLKFATEAAITILRIDD 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	124/575 (22%)
TCP1	NP_110379.2	TCP1_alpha	9..535	CDD:239451	126/582 (22%)