DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and Hspd1

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_071565.2	Gene:	Hspd1 / 63868	RGDID:	621314	Length:	573	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	414/575 - (72%)
Similarity:	483/575 - (84%)	Gaps:	9/575 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRYTNTLQRTAKISHVL---WARNYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIE 65
            |.|....|::...:|..|   ..|.|||||:||.:.||:||||||:||||||||||||||.||||
  Rat     1 MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIE 65

  Fly    66 QSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEK 130
            |||||||:|||||||||||.||||::||||||||||||||||||||||||||||||:||||||||
  Rat    66 QSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEK 130

  Fly   131 ISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGR 195
            ||:||:|||||||||||::.|...|::.|:||.|||||.|||||||||||.:||:||:|:|||||
  Rat   131 ISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGR 195

  Fly   196 DGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPA 260
            .|||||||||||.||||:|||||||||||||||||||||.|.|||||.:|..||||.|..|||||
  Rat   196 KGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPA 260

  Fly   261 LELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVF 325
            ||:|||.||||||||||::.|||||||:|||||||||.||||||||||||..|.|||:||||.||
  Rat   261 LEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVF 325

  Fly   326 GDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKM 390
            |:|...:.|||::..|.|:||||:|:|||.|||||||.||.:|||::.:.|.:..:||.|||||:
  Rat   326 GEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKL 390

  Fly   391 QERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQKLNDLK 455
            .||||:||.|||:|:|||:|||||:||||||.|||||||||||||||.|||.||||||..|:.||
  Rat   391 NERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLK 455

  Fly   456 GANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGDYGYDALKGEYGNMIERGIID 520
            .|||||.:|||||:|||::|.:||||||||:|:::|.|:.....:.||||:.|::.||:|:||||
  Rat   456 PANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIID 520

  Fly   521 PTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAAAGAAAGLGALGGMGMGGMG 575
            ||||||||:.||||||||||||||||||:|.||     ...|:||:|||| ||||
  Rat   521 PTKVVRTALLDAAGVASLLTTAEAVVTEIPKEE-----KDPGMGAMGGMG-GGMG 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	396/529 (75%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	390/519 (75%)
Hspd1	NP_071565.2	GroEL	28..548	CDD:239460	390/519 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341493
Domainoid	1	1.000	760	1.000	Domainoid score	I83
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	829	1.000	Inparanoid score	I432
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm45108
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810