DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsp60C and Mkks

DIOPT Version :9

Sequence 1:NP_608948.2 Gene:Hsp60C / 33796 FlyBaseID:FBgn0031728 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_001135418.1 Gene:Mkks / 59030 MGIID:1891836 Length:570 Species:Mus musculus


Alignment Length:520 Identity:83/520 - (15%)
Similarity:155/520 - (29%) Gaps:231/520 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 PKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGA 135
            |:.|::.:.:.|||.:..|.|.:                    |.:|||...:.:         |
Mouse   187 PESTEERMVLGKSIIVPLKGQRV--------------------TDSTVLPGLLIE---------A 222

  Fly   136 SPVEIRR--------GVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKK 192
            |.|::||        |:.:|:....     ||...:...|    ..:.|:...|:.|.:.|.:..
Mouse   223 SEVQLRRLLPTQKASGLRVALFCTS-----LSGDFSNAGE----GVVVAHYQVSLENAVLEQLLN 278

  Fly   193 VGRDGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSI 257
            :||         :.:.|.::                               |:.|:|.|.     
Mouse   279 LGR---------RLVTDHVD-------------------------------LVLCQKVIH----- 298

  Fly   258 VPALELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGG 322
             |:|:...::|               ..:.::|:.|.|                 :..::..||.
Mouse   299 -PSLKQFFSER---------------HVMAIDRVGVTL-----------------MESLSKVTGA 330

  Fly   323 IVFGDEANMVRLEDIKMSDFGRVGEVVVSKDD---------------TMLLKGKGQKAEVEKR-- 370
            ...|.      |..|..:.:|.|.:|..::..               |:||..:...|..|.:  
Mouse   331 TPIGS------LNPIVSTTYGSVKDVCSARFGSKHFFHLLPNEATVCTLLLCSRNDTAWEELKLT 389

  Fly   371 ----VEGLREAIKE------------STSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKD 419
                :..|:..|||            ..::|.:.|:..      ...|::|..|.:..::....:
Mouse   390 CQTAMHVLQLTIKEPWVLLGGGCTETHLAAYVRHKVHH------EAEAIVRDDGCTQAKLHVAAE 448

  Fly   420 RVIDALNATRAAVEEGIVPGGGTALL-------------------------RCIQKLNDLKGA-- 457
            ....||.:...::|.    .||..|:                         ||        |.  
Mouse   449 AFCSALESVAGSLEH----DGGEILIDTKYGHLWSCQADSASVGNWSDTLSRC--------GCGL 501

  Fly   458 -NEDQNMGIEIIRRA--------------------LRMPCLTIAKNAGVDGAMVVAKVEILDGDY 501
             |..:.:...::|..                    |.:.|.| ||.:|:..|:..|.: |||..|
Mouse   502 YNSQEELSWSVLRSTYHPFAPQTCLPQAALGSASNLTVDCFT-AKLSGLQVAVETANL-ILDLSY 564

  Fly   502  501
            Mouse   565  564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp60CNP_608948.2 PTZ00114 23..553 CDD:185455 83/520 (16%)
GroEL 28..548 CDD:239460 83/520 (16%)
MkksNP_001135418.1 Cpn60_TCP1 29..569 CDD:395068 83/520 (16%)
Substrate-binding apical domain. /evidence=ECO:0000250|UniProtKB:Q9NPJ1 198..370 44/293 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0459
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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