DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and CCT5

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	125/534 - (23%)
Similarity:	210/534 - (39%)	Gaps:	140/534 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RMFRYTNTLQRTAKISHVLWARNYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQS 67
            |..|.|.|   .|..:|::.||.                     :|..:..::||||.:.|:...
  Fly    25 RQKRITGT---DAIKTHIMAARQ---------------------IASTLKTSLGPKGLDKIMVSP 65

  Fly    68 WGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKIS 132
            .|...:|.||.|:.|.:.:..:.    |||:..::.:.::|.|||||...|||.|:.::....|.
  Fly    66 DGDVTVTNDGATIMKLMEVDHEI----AKLMVQLSQSQDDEIGDGTTGVVVLAGALLEQAEGLID 126

  Fly   133 RGASPVEIRRGVMLAIETVKDNLRRLSRPV----NTPEEICQVATISANGDKSVGNLISEAIKKV 193
            ||..|:.|..|..||.:.....|..:::|.    ...|.:.|:| ::..|.|.| |.....:.::
  Fly   127 RGIHPIRIADGFELAAQCAIKQLDAIAQPFPVDPKNKEPLIQIA-MTTLGSKIV-NKCHRQMAEM 189

  Fly   194 GRDGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALL---LFCEKKIKSA- 254
            ..|.|:.|.|.:......|:|:             |.|..|.::|  |::|   :..:|.:..:
  Fly   190 AVDAVLNVADIEKKDVNFELIK-------------IETKVGGRME--DSMLVKGVIVDKTLSHSQ 239

  Fly   255 -PSIVPALELA-----------NAQRKPLVIIAEDLEA-----EALSTLVVNRLKVGLQVCAVKA 302
             |..:..::||           ..:.|..|..|||..|     :...|.:|.::|......|:..
  Fly   240 MPKELRNVKLAILTCPFEPPKPKTKHKLDVTSAEDYRALREYEQEKFTQMVKQVKDAGATLAICQ 304

  Fly   303 PGFGDNRKENLMD----------------MAVATGGIVFGDEANMVRLEDIKMSDFGRVGEVVVS 351
            .||.|.....|:.                :|:||||.:      :.|.|::.....|
  Fly   305 WGFDDEANHLLLQQELPAVRWVGGPEIELIAIATGGRI------VPRFEELTPEKLG-------- 355

  Fly   352 KDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKM---QERLARLSSGVALLRVGGSSDVE 413
                               |.||   ::|......|:||   :|  .:.|..|.:...||::.:
  Fly   356 -------------------VAGL---VREMAFGTSKDKMLVIEE--CKNSKAVTIFLRGGNAMI- 395

  Fly   414 VSEKKDRVIDALNATRAAVEEG-IVPGGGTALLRCIQKLNDLKGANE-DQNMGIE-----IIRRA 471
            ::|.|..:.||:...|:.|::. ||.|||.|.:.|     .|..|.| ||...:|     ....|
  Fly   396 IAEAKRSIHDAICVVRSLVKDSRIVYGGGAAEISC-----SLAVAKEADQLSTLEQYAFRAFSVA 455

  Fly   472 LRMPCLTIAKNAGV 485
            |....|.:|:|:|:
  Fly   456 LESIPLALAENSGL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	119/514 (23%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	117/509 (23%)
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	125/534 (23%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	117/490 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453422
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740