DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and CCT4

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	114/564 - (20%)
Similarity:	224/564 - (39%)	Gaps:	92/564 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQN 92
            ||.....:||...:|....::||:..::||:|.:.:|:...|...||.||.|:.|.:       |
  Fly    18 KDKSKPTDVRLSNIQAAKAVSDAIRTSLGPRGMDKMIQAGNGEVSITNDGATILKQM-------N 75

  Fly    93 I---GAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDN 154
            :   .||::.:::...:..||||||:..|:|.|:.:...:.:.:|..|..|............:.
  Fly    76 VLHPAAKMLVELSRAQDVAAGDGTTSVVVIAGALLEACEKLLQKGLHPTAISDSFQRCSNKAVEI 140

  Fly   155 LRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGRDGVITVKD-GKTLCDELEVIEGMK 218
            |:::|.|:...:....:.:.|.:.:..|.:..|..:..:..|.|:.|.| ||....:|:.|:
  Fly   141 LKQMSTPIELDDRETLIKSASTSLNSKVVSQQSSLLAPIAVDAVLKVTDPGKETSVDLKNIK--- 202

  Fly   219 FDRGYISPYFINTSKGAKV---EFQDALLLFCEKKIKSAPSIVPALELA------NAQRKPL--- 271
                      :.:|.|..|   |..|.|:..|.....:||..:...::.      :|.:..:
  Fly   203 ----------VISSLGGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHN 257

  Fly   272 VIIAE--------DLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDE 328
            ||:::        ..|...:..:|....|.|..|..|        :|..|.| ||:.....|.|:
  Fly   258 VIVSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLV--------QKSILRD-AVSDLAQHFLDK 313

  Fly   329 ANMVRLEDIKMSDFGRVGEVV----VSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEK 389
            ...:.::|::..|...|.:.:    ::..|....:.......||:...|        |:.:.|..
  Fly   314 IKCMVVKDVEREDIEFVCKTLHCRPIASLDHFTAENLSSADLVEEVASG--------TNKFVKIT 370

  Fly   390 MQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVE-EGIVPGGGTALLRCIQKLND 453
            ..:.:.|..|.:.    .||:.:.:.|....:.|||...|..|: ...:.|||...:....:|..
  Fly   371 GIQNMGRTVSIIC----RGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAA 431

  Fly   454 LKGANEDQNMGIE-----IIRRALRMPCLTIAKNAGVDGAMVVAKVEIL----DGDYGYDALKGE 509
            |....|    |::     ....||.:...|:|:|||::....|.::...    :.:.|.:..||.
  Fly   432 LAQTVE----GVDAYCFRAFADALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKGA 492

  Fly   510 YGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEE 553
            ..::....::.|..|         .::|:....|.:.:.|.:::
  Fly   493 ITDIFAENVVQPLLV---------SISSITLATETIRSILKIDD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	114/562 (20%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	113/557 (20%)
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	114/564 (20%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	109/545 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740