DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and HSPD1

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_002147.2	Gene:	HSPD1 / 3329	HGNCID:	5261	Length:	573	Species:	Homo sapiens

Alignment Length:	575	Identity:	411/575 - (71%)
Similarity:	481/575 - (83%)	Gaps:	9/575 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRYTNTLQRTAKISHVL---WARNYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIE 65
            |.|.....::...:|.||   ..|.|||||:||.:.||:||||||:||||||||||||||.||||
Human     1 MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIE 65

  Fly    66 QSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEK 130
            |||||||:|||||||||||.||||::||||||||||||||||||||||||||||||:||||||||
Human    66 QSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEK 130

  Fly   131 ISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGR 195
            ||:||:|||||||||||::.|...|::.|:||.|||||.|||||||||||.:||:||:|:|||||
Human   131 ISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGR 195

  Fly   196 DGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPA 260
            .|||||||||||.||||:|||||||||||||||||||||.|.|||||.:|..||||.|..|||||
Human   196 KGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPA 260

  Fly   261 LELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVF 325
            ||:|||.||||||||||::.|||||||:|||||||||.||||||||||||..|.|||:||||.||
Human   261 LEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVF 325

  Fly   326 GDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKM 390
            |:|...:.|||::..|.|:||||:|:|||.|||||||.||::|||::.:.|.:..:||.|||||:
Human   326 GEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKL 390

  Fly   391 QERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQKLNDLK 455
            .||||:||.|||:|:|||:|||||:||||||.|||||||||||||||.|||.||||||..|:.|.
Human   391 NERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLT 455

  Fly   456 GANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGDYGYDALKGEYGNMIERGIID 520
            .|||||.:|||||:|.|::|.:||||||||:|:::|.|:.....:.||||:.|::.||:|:||||
Human   456 PANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIID 520

  Fly   521 PTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAAAGAAAGLGALGGMGMGGMG 575
            ||||||||:.|||||||||||||.||||:|.||     ...|:||:|||| ||||
Human   521 PTKVVRTALLDAAGVASLLTTAEVVVTEIPKEE-----KDPGMGAMGGMG-GGMG 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	393/529 (74%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	387/519 (75%)
HSPD1	NP_002147.2	GroEL	28..548	CDD:239460	387/519 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147670
Domainoid	1	1.000	750	1.000	Domainoid score	I92
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	822	1.000	Inparanoid score	I469
Isobase	1	0.950	-	0	Normalized mean entropy	S222
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm40974
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720