DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and Cct2

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_038934664.1	Gene:	Cct2 / 299809	RGDID:	1359143	Length:	561	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	133/582 - (22%)
Similarity:	219/582 - (37%)	Gaps:	161/582 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GVDVLADAVAVTMGPKGRNVIIEQSW--GSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNT 105
            |...:.|.|..|:||||.:.|:..|.  .|..:|.||.|:.|:|.:    .|..||::.|::...
  Rat    57 GAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGV----DNPAAKVLVDMSRVQ 117

  Fly   106 NEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTP----- 165
            ::|.|||||:.||||..:.:|....|::...|..|..|...|.:..::.|  ||..|:..
  Rat   118 DDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREAL--LSSAVDHGSDEVK 180

  Fly   166 --EEICQVA--TISA-----NGD-------------KSVGNLISEAIKKVGRDGVITVKDGKTLC 208
              :::..:|  |:|:     :.|             |..|||  |||.       :..|.|.:|.
  Rat   181 FWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNL--EAIH-------VIKKLGGSLA 236

  Fly   209 DELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCE-----KKIKSAPSIVPALELANAQR 268
            |..       .|.|::....|..::..::|  :|.:|...     .|||...|.|.....|.
  Rat   237 DSY-------LDEGFLLDKKIGVNQPKRIE--NAKILIANTGMDTDKIKIFGSRVRVDSTAK--- 289

  Fly   269 KPLVIIAEDLEAEALSTLVVNRLKVGLQ--------------------VCAVKAPGFGDNRKENL 313
               |...|..|.|.:...|...||.|:.                    |.|::...|....:
  Rat   290 ---VAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVER--- 348

  Fly   314 MDMAVATGGIVFG--DEANMVRLEDIKMSDFGRVGE--------VVVSKDDTMLLKGKGQKA--E 366
              :|:.|||.:..  |...:|:|...|:.:...:||        |.:.:..|::|:|..|:.  |
  Rat   349 --LALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDE 411

  Fly   367 VEKRVEG----LREAIKESTSSYEKEKMQERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNA 427
            .|:.:..    |.:.:|:..:.|.                    ||.|::            |.|
  Rat   412 AERSLHDALCVLAQTVKDPRTVYG--------------------GGCSEM------------LMA 444

  Fly   428 TRAAVEEGIVPGGGTALLRCIQKLNDLKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVA 492
            ....:.....||                    .:.:.:|...:||||....||.|||.|.|.:||
  Rat   445 HAVTMLASRTPG--------------------KEAVAMESFAKALRMLPTIIADNAGYDSADLVA 489

  Fly   493 KVEILDGD----YGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELP 550
            ::.....:    .|.|..:|..|:|...||.:..:|.|..:..||..|.::...:.::...|
  Rat   490 QLRAAHSEGRITAGLDMKEGSIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAP 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	133/582 (23%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	132/578 (23%)
Cct2	XP_038934664.1	TCP1_beta	37..553	CDD:239452	133/582 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810