DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and Cct7

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001100073.1	Gene:	Cct7 / 297406	RGDID:	1306422	Length:	544	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	129/576 - (22%)
Similarity:	228/576 - (39%)	Gaps:	106/576 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNT 105
            :....|:|:||..|:||:|.:.:|....|...|:.||.|:.|.:.:    .:..||.:.|:|.:.
  Rat    26 ISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDV----VHPAAKTLVDIAKSQ 86

  Fly   106 NEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEI-- 168
            :.|.|||||:.|:||....|:....:..|..|..|.|....|.:...:.::.::..|...:::
  Rat    87 DAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKQDKVEQ 151

  Fly   169 ------CQVATISANGDKSVGNLISEA---IKKVGRDGVITVKD-------------GKTLCDEL 211
                  |.:..:|:       .|||:.   ..|:..|.|:.:.:             |..| :|.
  Rat   152 RKMLEKCAMTALSS-------KLISQQKVFFAKMVVDAVMMLDELLQLKMIGIKKVQGGAL-EES 208

  Fly   212 EVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALELANAQRKPLVIIAE 276
            .::.|:.|.:.:....|....|  |.:.....||..|.::|:        |..||:.:  |...|
  Rat   209 RLVAGVAFKKTFSYAGFEMQPK--KYKNPKIALLNVELELKA--------EKDNAEIR--VHTVE 261

  Fly   277 DLEA--EALSTLVVNRL----KVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDE----ANM 331
            |.:|  :|...::.::|    :.|.:|...|.| .||          |||.  .|.|.    |..
  Rat   262 DYQAIVDAEWNILYDKLEKIHQSGAKVILSKLP-IGD----------VATQ--YFADRDMFCAGR 313

  Fly   332 VRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVE---GLREAIKESTSSYEKEKMQER 393
            |..||:|.               ||:..|...:..|...:.   |..:..:|:....|:......
  Rat   314 VPEEDLKR---------------TMMACGGSIQTSVNALIPDVLGRCQVFEETQIGGERYNFFTG 363

  Fly   394 LARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVE-EGIVPGGGTALLRCIQKLND---- 453
            ..:..:...:||.|....:|.:|:.  :.||:...|.|:: :.:|.|||...:...:.|.|
  Rat   364 CPKAKTCTIILRGGAEQFMEETERS--LHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRT 426

  Fly   454 LKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGD----YGYDALKGEYGNMI 514
            :.|   .|.:.|....:||.:....:..|||.|...::.|:......    ||.|....:..:..
  Rat   427 IPG---KQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNEDIADNF 488

  Fly   515 ERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAAAGAAAGLGALGGMG 570
            :..:.:|..|...|::.|:..|.|:.:.:..:.. |.....|...|||.|.  |.|
  Rat   489 QAFVWEPAMVRINALTAASEAACLIVSVDETIKN-PRSTVDAPAPAAGRGR--GQG 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	122/557 (22%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	121/552 (22%)
Cct7	NP_001100073.1	TCP1_eta	5..525	CDD:239456	122/556 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810