DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60C and Cct3

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_954522.1	Gene:	Cct3 / 295230	RGDID:	735038	Length:	545	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	111/555 - (20%)
Similarity:	219/555 - (39%)	Gaps:	89/555 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKL 97
            |.:|::..:.....:||.:...:|||....::....|...:|.||..:.:.|    :.|:..||.
  Rat    19 GRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREI----QVQHPAAKS 79

  Fly    98 VQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPV 162
            :.:::...:||.|||||:..:||..:.......:.:...|..:.....:|::.:...|:::|.||
  Rat    80 MIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMVSTLKKISTPV 144

  Fly   163 NTPEEICQVATISANGDKSV--------GNLISEAIKKV-----GRDGVITVKDGKT------LC 208
            :.......:..|:::....|        .|:..:|:|.|     ||..:...|..:.      :.
  Rat   145 DVNNRDMMLNIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGII 209

  Fly   209 DELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALELANAQRKPLVI 273
            ::..|:.|:..::....|......|..::...|:.|.:  ||.:|...|    |:...:....::
  Rat   210 EDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEY--KKGESQTDI----EITREEDFTRIL 268

  Fly   274 IAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDEANMVRLEDIK 338
               .:|.|.:..|..:.:::...| .:...|..|..:..||             .||:..:..::
  Rat   269 ---QMEEEYIQQLCEDIIQLKPDV-VITEKGISDLAQHYLM-------------RANVTAIRRVR 316

  Fly   339 MSDFGRV----GEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYE------KEKMQER 393
            .:|..|:    |..:||:.:.:.....|..|       ||.| ||:....|.      |:.
  Rat   317 KTDNNRIARACGARIVSRPEELREDDVGTGA-------GLLE-IKKIGDEYFTFITDCKDP---- 369

  Fly   394 LARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATR-AAVEEGIVPGGGTALLRCIQKLNDLKGA 457
                .:...||| |.|.:: :||.:..:.||:...| ..::..:|||||.:.:.....|.:...|
  Rat   370 ----KACTILLR-GASKEI-LSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKA 428

  Fly   458 NEDQNMGIE-----IIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGDYGYD--ALKGEYGNMI- 514
                ..|:|     .:.:||.:...|:.:|.|.....::..:.........:  .:.||.|.::
  Rat   429 ----MTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVD 489

  Fly   515 --ERGIIDPTKVVRTAISDAAGVASLLTTAEAVVT 547
              |.||.:|..|.......|...|.||...:.:|:
  Rat   490 MKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	111/555 (20%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	111/555 (20%)
Cct3	NP_954522.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		2/4 (50%)
		chap_CCT_gamma	6..529	CDD:274085	111/555 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900