DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60C and mcp60

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_592894.1	Gene:	mcp60 / 2543131	PomBaseID:	SPAC12G12.04	Length:	582	Species:	Schizosaccharomyces pombe

Alignment Length:	553	Identity:	296/553 - (53%)
Similarity:	411/553 - (74%)	Gaps:	7/553 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RNYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKD 88
            |.||||::||.:.||.:|.|||.||.||:||:|||||||:|:|.:|||||||||||||:|::|||
pombe    31 RTYAKDLKFGVDARASLLTGVDTLARAVSVTLGPKGRNVLIDQPFGSPKITKDGVTVARSVSLKD 95

  Fly    89 KFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKD 153
            ||:|:||:||||||:.|||.|||||||||||.|||..|....::.|.:|:::|||:.||::.|.:
pombe    96 KFENLGARLVQDVASKTNEVAGDGTTTATVLTRAIFSETVRNVAAGCNPMDLRRGIQLAVDNVVE 160

  Fly   154 NLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGRDGVITVKDGKTLCDELEVIEGMK 218
            .|:...|.:.|.|||.||||||||||..:|.|:::|:::||::||||||:|:|:.|||||.||||
pombe   161 FLQANKRDITTSEEISQVATISANGDTHIGELLAKAMERVGKEGVITVKEGRTISDELEVTEGMK 225

  Fly   219 FDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALELANAQRKPLVIIAEDLEAEAL 283
            |||||||||||...|..||||::.|:|..|||:.:...|:|:||||..||:||||||||::.|||
pombe   226 FDRGYISPYFITDVKSQKVEFENPLILLSEKKVSAVQDILPSLELAAQQRRPLVIIAEDVDGEAL 290

  Fly   284 STLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDEANMVRLEDIKMSDFGRVGEV 348
            :..::|:|:..|||.|:|||||||||:..|.|:||.|...||.||.: |.:|..:....|..|.|
pombe   291 AACILNKLRGQLQVVAIKAPGFGDNRRNMLGDLAVLTDSAVFNDEID-VSIEKAQPHHLGSCGSV 354

  Fly   349 VVSKDDTMLLKGKGQKAEVEKRVEGLREAIKE-STSSYEKEKMQERLARLSSGVALLRVGGSSDV 412
            .|:|:||:::||.|...:|..|.|.:|..:.: :.:.|||||:|||||:||.|:|:::|||||:|
pombe   355 TVTKEDTIIMKGAGDHVKVNDRCEQIRGVMADPNLTEYEKEKLQERLAKLSGGIAVIKVGGSSEV 419

  Fly   413 EVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQKLNDLKGANEDQNMGIEIIRRALRMPCL 477
            ||:|||||::|||||.:|||.||::||.||:.::...:|.|:...|.||.:|:||:|:|:..|..
pombe   420 EVNEKKDRIVDALNAVKAAVSEGVLPGAGTSFVKASLRLGDIPTNNFDQKLGVEIVRKAITRPAQ 484

  Fly   478 TIAKNAGVDGAMVVAKVEILDG---DYGYDALKGEYGNMIERGIIDPTKVVRTAISDAAGVASLL 539
            ||.:|||::|.::|.|::.|.|   :.|||..|..:.::.|.|::||.|||||.:.||:|||||:
pombe   485 TILENAGLEGNLIVGKLKELYGKEFNIGYDIAKDRFVDLNEIGVLDPLKVVRTGLVDASGVASLM 549

  Fly   540 TTAEAVVTELPLEEAAAAGAAAGLGALGGM-GM 571
            .|.|..:.:.|.|..|.|| ..|:|.:||| ||
pombe   550 GTTECAIVDAPEESKAPAG-PPGMGGMGGMPGM 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	285/532 (54%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	281/523 (54%)
mcp60	NP_592894.1	PTZ00114	29..564	CDD:185455	286/533 (54%)
mcp60	NP_592894.1	GroEL	35..558	CDD:239460	281/523 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	571	1.000	Domainoid score	I35
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I139
OMA	1	1.010	-	-		QHG61846
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm47177
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1504
TreeFam	1	0.960	-	-
	12	11.830