DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60C and cct3

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_775357.1	Gene:	cct3 / 192327	ZFINID:	ZDB-GENE-020419-5	Length:	543	Species:	Danio rerio

Alignment Length:	552	Identity:	105/552 - (19%)
Similarity:	216/552 - (39%)	Gaps:	83/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKL 97
            |.:|:...:.....:||.:...:||:....::....|...:|.||..:.:.|    :.|:..||.
Zfish    18 GRKVQIGNISAAKTIADIIRTCLGPRAMMKMLLDPMGGIVMTNDGNAILREI----QVQHPAAKS 78

  Fly    98 VQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPV 162
            :.:::...:||.|||||:..:||..:.....:.:.:...|..:......|::.:.:.|:.:|.||
Zfish    79 MIEISRTQDEEVGDGTTSVIILAGEMLSVAEQFLEQQMHPTVVIGAYRQALDDMLNILKDISTPV 143

  Fly   163 NTPEEICQVATI-SANGDKSVG-------NLISEAIKKV-----GRDGVITVKDGKT------LC 208
            :.......:..| ||...|::.       |:..:|::.|     ||:.:...|..|.      :.
Zfish   144 DVSNRDMMLKIINSAINTKALSRWSTLACNIALDAVRTVELDENGREEIDIKKYAKVEKVPGGII 208

  Fly   209 DELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPALELANAQRKPLVI 273
            ::..|:.|:..::....|......|..::     :||.|..:.|...|... :|:|..:....::
Zfish   209 EDSCVLRGVMVNKDVTHPRMRRLIKNPRI-----VLLDCSLEYKKGESQTD-IEIAREEDFARIL 267

  Fly   274 IAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDEANMVRLEDIK 338
            ..|:...:.:...:: |||..|   .....|..|..:..||             :||:..:..|:
Zfish   268 QMEEEYVQQICEDII-RLKPDL---IFTEKGISDLAQHYLM-------------KANITAIRRIR 315

  Fly   339 MSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLRE-AIKESTSSYEKEKMQERL------AR 396
            .:|..|:              .:...|.:..|.:.|.| .:...|..:|.:|:.:..      .:
Zfish   316 KTDNNRI--------------ARACGARIASRTDELTENDVGTGTGLFEVKKIGDEYFTFVTECK 366

  Fly   397 LSSGVALLRVGGSSDVEVSEKKDRVIDALNATR-AAVEEGIVPGGGTALLRCIQKLNDLKGANED 460
            ......:|..|.|.:: ::|.:..:.||:...| ..::..::||||...:....:|.:...|
Zfish   367 DPKACTILLRGASKEI-LAEVERNLQDAMQVCRNVLLDPYLLPGGGAVEMEVSHRLTERSRA--- 427

  Fly   461 QNMGIE-----IIRRALRMPCLTIAKNAGVDGAMVVAKVEIL-----DGDYGYDALKGEYGNMIE 515
             ..|:|     .:.:||.:...|:.:|.|.....|:..:...     :..:|.:...|...:|.:
Zfish   428 -MTGVEQWPYRAVAQALEVVPRTLIQNCGASAIRVLTSLRAKHTQEGNSSWGVNGETGTLADMEQ 491

  Fly   516 RGIIDPTKVVRTAISDAAGVASLLTTAEAVVT 547
            .||.:|..|.......|...|.||...:.:|:
Zfish   492 LGIWEPLAVKAQTYKTAVETAILLLRIDDIVS 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	105/552 (19%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	105/552 (19%)
cct3	NP_775357.1	chap_CCT_gamma	5..528	CDD:274085	105/552 (19%)
cct3	NP_775357.1	TCP1_gamma	5..524	CDD:239453	105/552 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900