DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and cct7

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_775355.1	Gene:	cct7 / 192324	ZFINID:	ZDB-GENE-020419-7	Length:	547	Species:	Danio rerio

Alignment Length:	572	Identity:	129/572 - (22%)
Similarity:	233/572 - (40%)	Gaps:	108/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNT 105
            :....|:|:||..|:||:|.:.::..:.|...|:.||.|:.|.:.:    .:..||.:.|:|.:.
Zfish    26 INACQVVAEAVRTTLGPRGMDKLVVDNRGKATISNDGATILKLLDV----VHPAAKTLVDIARSQ 86

  Fly   106 NEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPE---- 166
            :.|.|||||:.|:||....|:....:..|..|..|.|...:|.:.....::.::..:...:
Zfish    87 DAEVGDGTTSVTLLAAEFLKQLKPYVEEGLHPQTIIRAFRIATQLAVKKIKEIAVTIKKDDKQEQ 151

  Fly   167 ----EICQVATISAN---GDKS-VGNLISEAIKKVGRDGVITVK-------DGKTLCDELEVIEG 216
                |.|....:::.   |.|. ...::.:|:..:  |.::.:|       .|..| :|.:::.|
Zfish   152 RRLLEKCAATALNSKLIAGQKDFFSKMVVDAVMML--DDLLPLKMIGVKKVQGGAL-EESQLVAG 213

  Fly   217 MKFDRGYISPYFINTSKGAKVEFQ-------DALLLFCEKKIKSAPSIVPALELANAQRKPLVII 274
            :.|.:         |...|..|.|       ...||..|.::|:        |..||:.:  |..
Zfish   214 VAFKK---------TFSYAGFEMQPKRYMNPKIALLNIELELKA--------EKDNAEVR--VNS 259

  Fly   275 AEDLEA--EALSTLVVNRL----KVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGD---EAN 330
            .||.:|  :|...::.::|    |.|.:|...|.| .||          |||....:.:   .|.
Zfish   260 MEDYQAIVDAEWNILYDKLEKIHKSGAKVVLSKLP-IGD----------VATQYFAYRNLFCAAR 313

  Fly   331 MVRLEDIK---MSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKMQE 392
            :|. |::|   |:..|.:...|.|..|.:|               |..|..:|.....|:....:
Zfish   314 VVE-ENLKRTMMACGGSIQTSVGSLTDDVL---------------GQCELFEEVQVGGERYNFFK 362

  Fly   393 RLARLSSGVALLRVGGSSDVEVSEKKDRVI-DALNATRAAVE-EGIVPGGGTALLRCIQKLND-- 453
            ...:..:...:|| ||:.  :..|:.||.: ||:...|.|:: :.||.|||...:...:.|.|
Zfish   363 GCPKAKTCTIILR-GGAE--QFMEETDRSLHDAIMIVRRAIKNDSIVAGGGAIEMELSKYLRDYS 424

  Fly   454 --LKGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGD----YGYDALKGEYGN 512
              :.|   .|.:.|....:||.:....:..|||.|...::.|:......    ||.|....:..:
Zfish   425 RTIPG---KQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRAKHAQGGMWYGVDVNNEDIAD 486

  Fly   513 MIERGIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAAAGAAAGLG 564
            ..:..:.:|:.|...|::.|:..|.|:.:.:..:.. |........||||.|
Zfish   487 NFQACVWEPSIVRINALTAASEAACLILSVDETIKN-PRSSVDGPPAAAGRG 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	124/559 (22%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	123/554 (22%)
cct7	NP_775355.1	chap_CCT_eta	4..525	CDD:274086	124/558 (22%)
cct7	NP_775355.1	TCP1_eta	5..525	CDD:239456	124/558 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810