DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and hsp-60

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_497429.1	Gene:	hsp-60 / 175316	WormBaseID:	WBGene00002025	Length:	568	Species:	Caenorhabditis elegans

Alignment Length:	580	Identity:	382/580 - (65%)
Similarity:	463/580 - (79%)	Gaps:	18/580 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMRMFRYTNTLQRTAKISHVLWARNYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIE 65
            |:|:.|  ..|| ||.:      |:|||||:||.|.|..||.||::|||||:|||||||||||||
Worm     1 MLRLAR--KGLQ-TAVV------RSYAKDVKFGAEGRQAMLVGVNLLADAVSVTMGPKGRNVIIE 56

  Fly    66 QSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEK 130
            |||||||||||||||||||.||||:||:||||:|||||..|||||||||.||||||||||||||.
Worm    57 QSWGSPKITKDGVTVAKSIDLKDKYQNLGAKLIQDVANKANEEAGDGTTCATVLARAIAKEGFES 121

  Fly   131 ISRGASPVEIRRGVMLAIETVKDNLRRLSRPVNTPEEICQVATISANGDKSVGNLISEAIKKVGR 195
            |.:|.:.||||||||.|:|.|...|:::|:.|.|||||.||||||||||..||||||:|:||||.
Worm   122 IRQGGNAVEIRRGVMNAVEVVVAELKKISKKVTTPEEIAQVATISANGDTVVGNLISDAMKKVGT 186

  Fly   196 DGVITVKDGKTLCDELEVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSIVPA 260
            .|||||||||||.||||:||||||||||||||||.::||||||::.||:|..||||.....||||
Worm   187 TGVITVKDGKTLNDELELIEGMKFDRGYISPYFITSAKGAKVEYEKALVLLSEKKISQVQDIVPA 251

  Fly   261 LELANAQRKPLVIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVF 325
            |||||..|:||||||||::.|||:|||:|||||||||.|:||||||||||..|.||.:|||..:|
Worm   252 LELANKLRRPLVIIAEDVDGEALTTLVLNRLKVGLQVVAIKAPGFGDNRKNTLKDMGIATGATIF 316

  Fly   326 GDEANMVRLEDIKMSDFGRVGEVVVSKDDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKM 390
            ||::|::::|||..:|.|.|.||.::||||:||:|:|.:.|:|||:|.:.:.|::|||.|||||:
Worm   317 GDDSNLIKIEDITANDLGEVDEVTITKDDTLLLRGRGDQTEIEKRIEHITDEIEQSTSDYEKEKL 381

  Fly   391 QERLARLSSGVALLRVGGSSDVEVSEKKDRVIDALNATRAAVEEGIVPGGGTALLRCIQKLNDLK 455
            .||||:||.|||:|::||.|:|||.||||||.|||.|||||||||||||||.||||.:..|.:.|
Worm   382 NERLAKLSKGVAVLKIGGGSEVEVGEKKDRVTDALCATRAAVEEGIVPGGGVALLRSLTALKNYK 446

  Fly   456 GANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKVEILDGD----YGYDALKGEYGNMIER 516
            .|||||.:|:.|:::||..|..||.||||::.:.::.:|   .|:    ||||||.|::.:|.|.
Worm   447 AANEDQQIGVNIVKKALTQPIATIVKNAGLEPSSIIDEV---TGNSNTSYGYDALNGKFVDMFEA 508

  Fly   517 GIIDPTKVVRTAISDAAGVASLLTTAEAVVTELPLEEAAAAGAAAGLGALGGM-GMGGMG 575
            ||||||||||||:.||:||||||.|.|.||||:|.|| |..|.|.|:|.:||| ||||||
Worm   509 GIIDPTKVVRTALQDASGVASLLATTECVVTEIPKEE-AVGGPAGGMGGMGGMGGMGGMG 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	359/533 (67%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	353/523 (67%)
hsp-60	NP_497429.1	PTZ00114	14..546	CDD:185455	361/541 (67%)
hsp-60	NP_497429.1	GroEL	19..540	CDD:239460	353/523 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159663
Domainoid	1	1.000	702	1.000	Domainoid score	I52
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	769	1.000	Inparanoid score	I274
Isobase	1	0.950	-	0	Normalized mean entropy	S222
OMA	1	1.010	-	-		QHG61846
OrthoDB	1	1.010	-	-		D183447at33208
OrthoFinder	1	1.000	-	-		FOG0001450
OrthoInspector	1	1.000	-	-		otm14334
orthoMCL	1	0.900	-	-		OOG6_100393
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1504
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.860