DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60C and CCT4

DIOPT Version :9

Sequence 1:	NP_608948.2	Gene:	Hsp60C / 33796	FlyBaseID:	FBgn0031728	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_006421.2	Gene:	CCT4 / 10575	HGNCID:	1617	Length:	539	Species:	Homo sapiens

Alignment Length:	553	Identity:	130/553 - (23%)
Similarity:	238/553 - (43%)	Gaps:	86/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIALKDKFQNIGAKLVQ 99
            ::|...:.....:|||:..::||||.:.:|:...|...||.||.|:.|.:    :..:..|:::.
Human    32 QIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQM----QVLHPAARMLV 92

  Fly   100 DVANNTNEEAGDGTTTATVLARAIAKEGFEKISRGASPVEIRRGVMLAIETVKDNLRRLSRPV-- 162
            :::...:.|||||||:..::|.::.....:.:.:|..|..|......|:|...:.|..:||||
Human    93 ELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPVEL 157

  Fly   163 NTPEEICQVATISANGD--KSVGNLIS----EAIKKV----------GRDGVITVKDGKTLCDEL 211
            :..|.:...||.|.|..  ....:|:|    .|:.||          .||..|..|.|.|: |:.
Human   158 SDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTI-DDC 221

  Fly   212 EVIEGMKFDRGYISPYFINTSKGAKVEFQDALLLFCEKKIKSAPSI-----VPALELANAQRKPL 271
            |::||:...: .:|...|...:.||:    .|:.||    .|||..     :...:.|...|
Human   222 ELVEGLVLTQ-KVSNSGITRVEKAKI----GLIQFC----LSAPKTDMDNQIVVSDYAQMDR--- 274

  Fly   272 VIIAEDLEAEALSTLVVNRLKVGLQVCAVKAPGFGDNRKENLMDMAVATGGIVFGDEANMVRLED 336
             ::.|  |...:..||....|.|..|..:        :|..|.| |::...:.|.::..::.::|
Human   275 -VLRE--ERAYILNLVKQIKKTGCNVLLI--------QKSILRD-ALSDLALHFLNKMKIMVIKD 327

  Fly   337 IKMSDFGRVGEVVVSK------DDTMLLKGKGQKAEVEKRVEGLREAIKESTSSYEKEKMQERLA 395
            |:..|...:.:.:.:|      ..|..:.|..:.|| |..:.|..:.:|.:..:
Human   328 IEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAE-EVNLNGSGKLLKITGCA----------- 380

  Fly   396 RLSSG-VALLRVGGSSDVEVSEKKDRVIDALNATRAAVEE-GIVPGGGT----ALLRCIQKLNDL 454
              |.| ...:.|.||:.:.:.|.:..:.|||...|..|:: .::.|||.    ..||..:....|
Human   381 --SPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTL 443

  Fly   455 KGANEDQNMGIEIIRRALRMPCLTIAKNAGVDGAMVVAKV--EILDGD--YGYDALKGEYGNMIE 515
            .|.   ::..:.....|:.:...|:|:|||::....|.::  ....|:  .|.:..||...|::|
Human   444 SGM---ESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTAGINVRKGGISNILE 505

  Fly   516 RGIIDPTKVVRTAISDAA-GVASLLTTAEAVVT 547
            ..::.|..|..:|::.|. .|.|:|...:.|.|
Human   506 ELVVQPLLVSVSALTLATETVRSILKIDDVVNT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60C	NP_608948.2	PTZ00114	23..553	CDD:185455	130/553 (24%)
Hsp60C	NP_608948.2	GroEL	28..548	CDD:239460	130/553 (24%)
CCT4	NP_006421.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
CCT4	NP_006421.2	TCP1_delta	25..538	CDD:239454	129/551 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810