DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and Kirrel3

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	578	Identity:	129/578 - (22%)
Similarity:	208/578 - (35%)	Gaps:	163/578 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QNKDELLEDIREDTVVNAIPEKDLPKFGELL---QNVTVPVSREAVLQCVVDNLQTYKIAWLRVD 167
            |.:|:::...:..|::.||||.|    |.:|   ..:.:.|.|:         |.:|
Mouse    53 QPQDQVVVSGQPVTLLCAIPEYD----GFVLWIKDGLALGVGRD---------LSSY-------- 96

  Fly   168 TQTILTIQNHVITKNHRMSITHAEKRAWILRIRDVKESDKGWYMCQINTDPMKSQVGYLDVVVPP 232
             ...|.:.|| ::..|.:.|..||.:            |...|.||.....::|:...|.|:|||
Mouse    97 -PQYLVVGNH-LSGEHHLKILRAELQ------------DDAVYECQAIQAAIRSRPARLTVLVPP 147

  Fly   233 D---ILDYPTSTDMVIREGSNVTLKC-AATGSPTPTITWRREGGELIPLPNGAEAVAYNGSFLTI 293
            |   ||..|.   :.:|.|..:.|.| |....|..:|.|.|: ||:|   |||   .|:.:.|..
Mouse   148 DDPIILGGPV---ISLRAGDPLNLTCHADNAKPAASIIWLRK-GEVI---NGA---TYSKTLLRD 202

  Fly   294 AK----VNRL--------NMGAYLCIASN-GIPPTVSKRVMLIVHFPPMI--WIQNQLVGAALTQ 343
            .|    |:.|        |..:.:|.|:| .||......|.:.:..||::  .::.|.|   |..
Mouse   203 GKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPV---LED 264

  Fly   344 NI-TLECQSEAYPKSINY-WMKNDTII--VPGERFVPETFESGYKITMRLTIYEVDIQDFGAYRC 404
            || |..|.::|.|....| |.|...||  ..||.         |:.|:..|.:...:.      |
Mouse   265 NIVTFHCSAKANPAVTQYRWAKRGHIIKEASGEL---------YRTTVDYTYFSEPVS------C 314

  Fly   405 VAKNSLGDTD--GAIKLYHIPQTTT-----------------------------MTTMAPTVSIN 438
            ...|:||.|:  ..:.:|..|:.|:                             |...:..|..|
Mouse   315 EVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPSLTIVWMKRGSGVVLSN 379

  Fly   439 TVPVVLVKYNKEQ-----------RYGSSQNSNTNPYNFNPGNSQQNTKLQRGKSNSKG------ 486
            ...:.|....:|.           |.|:.:...|...|..|..|  :|:.|......||
Mouse   380 EKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIIS--STQTQHALHGEKGQIKCFI 442

  Fly   487 -SDQSP-----SGLNNVFVGATSSLWNSQDHHSSSS--SSSSASSRGRDHHQQQHHQQQQQNHGS 543
             |...|     |...||....||..:..:..::...  |:.:.|:..|...|..::.....:.||
Mouse   443 RSTPPPDRIAWSWKENVLESGTSGRYTVETVNTEEGVISTLTISNIVRADFQTIYNCTAWNSFGS 507

  Fly   544 DHGASYRSDGKSPHLTNHDAKSLTDDLDRMQDLKGWASRLSPISPILGLSMILGVGYL 601
            |                .:...|.:....|:...|..:...|::.|:|:::..||.:|
Mouse   508 D----------------TEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	18/92 (20%)
		IG_like	137..230	CDD:214653	18/92 (20%)
		IG_like	240..324	CDD:214653	27/97 (28%)
		IGc2	247..310	CDD:197706	22/75 (29%)
		Ig	327..419	CDD:299845	26/99 (26%)
		IG_like	343..420	CDD:214653	21/82 (26%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	26/123 (21%)
		Ig strand A'	56..60	CDD:409353	1/3 (33%)
		Ig strand B	64..71	CDD:409353	1/6 (17%)
		Ig strand C	78..82	CDD:409353	1/3 (33%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/3 (0%)
		Ig strand E	104..116	CDD:409353	4/12 (33%)
		Ig strand G	132..143	CDD:409353	2/10 (20%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	30/106 (28%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	1/3 (33%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	20/81 (25%)
		Ig strand B	267..274	CDD:409353	2/6 (33%)
		Ig strand C	279..286	CDD:409353	2/6 (33%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	1/12 (8%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	3/12 (25%)
		Ig	335..416	CDD:416386	10/80 (13%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	0/9 (0%)
		Ig strand C	365..371	CDD:409353	1/5 (20%)
		Ig strand E	381..387	CDD:409353	1/5 (20%)
		IgI_5_KIRREL3	418..515	CDD:409479	20/114 (18%)
		Ig strand B	436..440	CDD:409479	1/3 (33%)
		Ig strand C	450..454	CDD:409479	0/3 (0%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	0/4 (0%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810