DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-theta and kirrel3b

DIOPT Version :9

Sequence 1:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	XP_021323594.1	Gene:	kirrel3b / 572369	ZFINID:	ZDB-GENE-100713-3	Length:	795	Species:	Danio rerio

Alignment Length:	384	Identity:	93/384 - (24%)
Similarity:	145/384 - (37%)	Gaps:	83/384 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 MQNKDELLEDIREDTVVNAIPEKDLPKFGELL----QNVTVPVSREAVLQCVVDNLQTYKIAWLR 165
            |.:|..|.:..||.||..........:.|:.:    .|..||..:|.   .|..::|...:..|.
Zfish   175 MYSKTLLRDGRRESTVSTLYISASNIESGQKIICRASNKAVPNGKET---SVTIDIQHLPLVNLS 236

  Fly   166 VDTQTIL---TIQNHVITKNHRMSITHAEKRAWILRIRDVKESDKGWYMCQIN----TDPMKSQV 223
            |:.|.:|   .::.|...|.: ..:|..:   |......:||.....|...::    |:|:..:|
Zfish   237 VEPQPVLEGNLVKFHCSAKAN-PPVTQYK---WAKGGSVIKEVSGDTYEVIVDHSFFTEPVSCEV 297

  Fly   224 ----------GYLDVVVPPDILDYPTSTDMVIREGSNVTLKCAATGSPTPTITWRREGGELIPLP 278
                      ..:||...|.:...|.|..:.:  ||:....||.||:|:.||.|         :.
Zfish   298 TNPLGSTNISRNVDVYFGPRMAAEPQSLQVDL--GSDAVFNCAWTGNPSLTIVW---------MK 351

  Fly   279 NGAEAVAYNGSFLTIAKVNRLNMGAYLCIASNGIPPTV---SKRVMLIVHFPPMIWIQNQLVGAA 340
            .|:..|..|.:.||:..|.:.:.|.|:|.|   :.|.|   .|.|.|.|:.||.| ...|...|.
Zfish   352 RGSGVVLSNENILTLKSVRQEDAGKYVCRA---VVPRVGAAEKEVSLTVNGPPTI-SSTQTHQAP 412

  Fly   341 LTQNITLEC--QSEAYPKSINYWMKNDTIIVPGE--RFVPETFESGYKITMRLTIYEVDIQDFGA 401
            ..:...::|  :|...|..| .|...:|::..|.  |:..||..:...:...||:..:...||..
Zfish   413 HGEKGQIKCFIRSTPPPDRI-AWSWKETVLESGTSGRYTVETVSTEDGVLSTLTMSNIVPADFQT 476

  Fly   402 -YRCVAKNSLGDTDGAIKLYHIPQTTTMTTMAPTVSINTVPVVLVKYNKEQRYGSSQNS 459
             |.|.|.||.|.....|:|                             |||  |.||:|
Zfish   477 IYNCTAWNSFGSDTEIIRL-----------------------------KEQ--GGSQDS 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	22/109 (20%)
		IG_like	137..230	CDD:214653	22/109 (20%)
		IG_like	240..324	CDD:214653	26/86 (30%)
		IGc2	247..310	CDD:197706	20/62 (32%)
		Ig	327..419	CDD:299845	26/96 (27%)
		IG_like	343..420	CDD:214653	21/81 (26%)
kirrel3b	XP_021323594.1	IG_like	35..124	CDD:214653
		Ig2_KIRREL3-like	146..227	CDD:143236	13/54 (24%)
		Ig_2	235..312	CDD:316418	14/80 (18%)
		I-set	316..397	CDD:333254	28/94 (30%)
		Ig5_KIRREL3	399..496	CDD:143306	27/127 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910